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dc.creatorGreenwood, Tiffany A.
dc.creatorBeeri, Michal S.
dc.creatorSchmeidler, James
dc.creatorValerio Aguilar, Daniel
dc.creatorRaventós Vorst, Henriette
dc.creatorMora Villalobos, Lara
dc.creatorCamacho, Karla
dc.creatorCarrión Baralt, José R.
dc.creatorAngelo, Gary
dc.creatorAlmasy, Laura
dc.creatorSano, Mary
dc.creatorSilverman, Jeremy M.
dc.date.accessioned2014-04-22T16:34:56Z
dc.date.available2014-04-22T16:34:56Z
dc.date.issued2011
dc.identifier.issn1387-2877
dc.identifier.otheressn: 1875-8908
dc.identifier.urihttp://hdl.handle.net/10669/11042
dc.descriptionartículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigación en Biología Celular y Molecular. Escuela de Biología, 2011es
dc.description.abstractWe sought to identify cognitive phenotypes for family/genetic studies of successful cognitive aging (SCA; maintaining intact cognitive functioning while living to late old age).We administered a battery of neuropsychological tests to nondemented nonagenarians (n = 65; mean age = 93.4±3.0) and their offspring (n = 188; mean age = 66.4±5.0) from the Central Valley of Costa Rica. After covarying for age, gender, and years of education, as necessary, heritability was calculated for cognitive functions at three pre-defined levels of complexity: specific neuropsychological functions (e.g., delayed recall, sequencing), three higher level cognitive domains (memory, executive functions, attention), and an overall neuropsychological summary. The highest heritability was for delayed recall (h2 = 0.74, se = 0.14, p < 0.0001) but significant heritabilities involving memory were also observed for immediate recall (h2 = 0.50), memory as a cognitive domain (h2 = 0.53), and the overall neuropsychological summary (h2 = 0.42). Heritabilities for sequencing (h2 = 0.42), fluency (h2 = 0.39), abstraction (h2 = 0.36), and the executive functions cognitive domain (h2 = 0.35) were also significant. In contrast, the attention domain and memory recognition were not significantly heritable in these families. Among the heritable specific cognitive functions, a strong pleiotropic effect (i.e., evidence that these may be influenced by the same gene or set of genes) for delayed and immediate recall was identified (bivariate statistic = 0.934, p < 0.0001) and more modest but significant effects were found for four additional bivariate relationships. The results support the heritability of good cognitive function in old age and the utilization of several levels of phenotypes, and they suggest that several measures involving memory may be especially useful for family/genetic studies of SCA.es
dc.description.sponsorshipUniversidad de Costa Ricaes
dc.language.isoen_USes
dc.publisherJ Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782.es
dc.subjectFenotipoes
dc.subjectGenéticaes
dc.subjectNeurofisioogíaes
dc.subjectEnvejecimiento cognitivoes
dc.subjectCosta Ricaes
dc.titleHeritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Ricaes
dc.typeArtículo científicoes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.3233/JAD-2011-110782
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es


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