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Mitochondrial polymorphisms are associated both with increased and decreased longevity

Artículo científico
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Mitochondrial Polymorphisms Are associated both with increated and decreased longevity.pdf (123.5Kb)
Date
2008-12-15
Author
Castri, Loredana
Meléndez Obando, Mauricio O.
Villegas Palma, Ramón
Barrantes Mesén, Ramiro
Raventós Vorst, Henriette
Pereira Reyes, Reinaldo
Luiselli, Donata
Pettener, Davide
Madrigal, Lorena
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Abstract
Previous work compared frequency of longevity-associated polymorphisms (LAPS) in long-lived individuals and in controls from the general population (primarily in Europe and Japan), suggesting the polymorphisms are responsible for unusual longevity. However, individuals from the general population are not the control group for long-lived subjects because both were born in different periods. We report results of a project which collected mtDNA from living subjects in Costa Rica, and traced back their maternal genealogy. Since mtDNA does not recombine and its probability of mutation is low, we can assume that the maternal ancestors had the same mtDNA of their descendants. We compared the longevity of individuals with LAPS with the longevity of controls born in the same time period. We did not confirm previous associations for several markers, but found that the 5178A mutation in haplogroup D is associated with decreased longevity, whereas the 150T mutation is associated with increased longevity. These associations however, are not significant for all time periods under study. While our data confirm that mtDNA make up affects longevity, they also indicate that the time period in which a person was born had a much greater impact on longevity than presence or absence of a marker.
URI
http://hdl.handle.net/10669/11045
External link to the item
10.1159/000181152
http://www.karger.com/Article/Pdf/181152
artículo (arbitrado) -- Universidad de Costa Rica, Centro de investigaciones en Biología Celular y Molecular, 2008. Este documento es privado debido a limitaciones de derechos de autor.
 
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  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica