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dc.creatorSequeira Cordero, Andrey
dc.creatorMora Gallegos, Andrea
dc.creatorCuenca Berger, Patricia
dc.creatorFornaguera Trías, Jaime
dc.date.accessioned2014-12-16T21:23:00Z
dc.date.available2014-12-16T21:23:00Z
dc.date.issued2014-02-08
dc.identifier.issn0031-9384
dc.identifier.otheressn:1873-507X
dc.identifier.urihttp://hdl.handle.net/10669/11253
dc.descriptionartículo -- Universidad de Costa Rica, Instituto de Investigaciones en Salud y Centro de Investigación en Neurociencias. 2014. Este documento es privado debido a limitaciones de derechos de autor.es_ES
dc.description.abstractIndividual differences in the forced swimming test (FST) could be associatedwith differential temporal dynamics of gene expression and neurotransmitter activity. We tested juvenile male rats in the FST and classified the animals into those with low and high immobility according to the amount of immobility time recorded in FST. These groups and a control group which did not undergo the FST were sacrificed either 1, 6 or 24 h after the test. We analyzed the expression of the CRF, CRFR1, BDNF and TrkB in the prefrontal cortex, hippocampus and nucleus accumbens as well as norepinephrine, dopamine, serotonin, glutamate, GABA and glutamine in the hippocampus and nucleus accumbens. Animals with low immobility showed significant reductions of BDNF expression across time points in both the prefrontal cortex and the nucleus accumbens when compared with non-swim control. Moreover, rats with high immobility only showed a significant decrease of BDNF expression in the prefrontal cortex 6 h after the FST. Regarding neurotransmitters, only accumbal dopamine turnover and hippocampal glutamate content showed an effect of individual differences (i.e. animals with low and high immobility), whereas nearly all parameters showed significant differences across time points. Correlational analyses suggest that immobility in the FST, probably reflecting despair, is related to prefrontal cortical BDNF and to the kinetics observed in several other neurochemical parameters. Taken together, our results suggest that individual differences observed in depression-like behavior can be associated not only with changes in the concentrations of key neurochemical factors but also with differential time courses of such factors.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[742-A9-120 ]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.publisherPhysiology & Behavior 126(1):60-69es_ES
dc.subjectBDNF expressiones_ES
dc.subjectBraines_ES
dc.subjectNeurotransmitterses_ES
dc.subjectGenéticaes_ES
dc.titleIndividual differences in the forced swimming test and neurochemical kinetics in the rat braines_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.physbeh.2014.01.037
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)
dc.identifier.codproyecto742-A9-120


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