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dc.creatorSun, Guangyun
dc.creatorMcGarvey, Stephen T.
dc.creatorBayoumi, Riad
dc.creatorMulligan, Connie J.
dc.creatorBarrantes Mesén, Ramiro
dc.creatorRaskin, Salmo
dc.creatorZhong, Yixi
dc.creatorAkey, Joshua
dc.creatorChakraborty, Ranajit
dc.creatorDeka, Ranjan
dc.date.accessioned2015-04-20T20:36:30Z
dc.date.available2015-04-20T20:36:30Z
dc.date.issued2003-01
dc.identifier.citationhttp://www.nature.com/ejhg/journal/v11/n1/full/5200902a.htmles_ES
dc.identifier.issn1018-4813
dc.identifier.urihttp://hdl.handle.net/10669/11393
dc.descriptionArtículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2003es_ES
dc.description.abstractWe have studied genetic variation at nine autosomal short tandem repeat loci in 20 globally distributed human populations defined by geographic and ethnic origins, viz., African, Caucasian, Asian, Native American and Oceanic. The purpose of this study is to evaluate the utility and applicability of these nine loci in forensic analysis in worldwide populations. The levels of genetic variation measured by number of alleles, allele size variance and heterozygosity are high in all populations irrespective of their effective sizes. Single- as well as multi-locus genotype frequencies are in conformity with the assumptions of Hardy-Weinberg equilibrium. Further, alleles across the entire set of nine loci are mutually independent in all populations. Gene diversity analysis shows that pooling of population data by major geographic groupings does not introduce substructure effects beyond the levels recommended by the National Research Council, validating the establishment of population databases based on major geographic and ethnic groupings. A network tree based on genetic distances further supports this assertion, in which populations of common ancestry cluster together. With respect to the power of discrimination and exclusion probabilities, even the relatively reduced levels of genetic variation at these nine STR loci in smaller and isolated populations provide an exclusionary power over 99%. However, in paternity testing with unknown genotype of the mother, the power of exclusion could fall below 80% in some isolated populations, and in such cases use of additional loci supplementing the battery of the nine loci is recommended.es_ES
dc.description.sponsorshipUniversidad de Costa Rica. Instituto de Investigaciones en Saludes_ES
dc.language.isoen_USes_ES
dc.publisherEuropean Journal of Human Genetics (2003) 11, 39 – 49es_ES
dc.sourceEuropean Journal of Human Genetics 11: 39-49es_ES
dc.subjectforensic geneticses_ES
dc.subjectpopulation geneticses_ES
dc.subjectSTR databasees_ES
dc.subjectforensic markerses_ES
dc.subjectparentage testinges_ES
dc.subjectHardy – Weinberg equilibriumes_ES
dc.subjectGeneticses_ES
dc.titleGlobal genetic variation at nine short tandem repeat loci and implications on forensic geneticses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1038/sj.ejhg.5200902
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA)es_ES


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