Listar Investigación por título
Mostrando ítems 1-20 de 6747
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20 años de Estam/Pasión 1989-2009
(SIEDIN, 2009-07-02)Catálogo de la exposición retrospectiva, realizada en el Instituto de México en San José, en julio de 2009. Es una muestra representativa de veinte años de producción artística. Reúne más de setenta obras del artista, ... -
¡200 Petabytes a 100 Megadólares!: Surá – Clúster para el almacenamiento y procesamiento de datos científicos del PRIS-LAB.
(2014-01-10)Póster presentado en la III Conferencia Internacional de Acceso Abierto, Preservación Digital y Datos científicos (Biredial-SIBD) 15-17 de octubre de 2013. El desarrollo de sistemas computacionales más poderosos en la ... -
25 Years of the Internet in Central America: an interview with Guy de Téramond
(2017-10)January 2018 marks the 25th anniversary of the first dedicated Internet connection in Central America. Little is known about the conditions that characterised the early development of the Internet in this part of the globe. ... -
A biocomputational platform for the automated construction of large-scale mathematical models of miRNA-transcription factor networks for studies on gene dosage compensation
(2016-11-09)Cancer complexity and resistance is mediated by cell-to-cell heterogeneity, which is the consequence of the enormous instability of its genetic material. It is unknown how cancer cells are able to withstand the effects ... -
A bright future for integrative venomics
(2015-10)Venomous secretions are produced by a myriad of animal species, from invertebrates to vertebrates. As a general rule, peptides and proteins represent the most abundant and functionally relevant components of these dangerous ... -
A Call for Incorporating Social Research in the Global Struggle against Snakebite
(2015-09-17)In Africa, Asia, Latin America, and parts of Oceania, envenoming after snakebite is a serious public health problem. Conservative data suggest that between 1.2 and 5.5 million people suffer snakebites every year, resulting ... -
A call-and-response system facilitates group cohesion among disc-winged bats
(2013)Acoustic signals are important in maintaining group cohesion, particularly in highly mobile species. For these signals to facilitate group cohesion, individuals must be able to recognize, and respond to, calls emitted by ... -
A case-control study of breast cancer and hormonal contraception in Costa Rica
(1987)By 1981, 11% of married women in Costa Rica ages 20-49 years had used depot-medroxyprogesterone acetate (DMPA) and 58% had used oral contraceptives (OCs). Since 1977, the Costa Rican Ministry of Health has maintained a ... -
A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages
(2013-05-15)The effects of a snakevenom Lys-49phospholipaseA2 (PLA2) homolog named MT-II,devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2(COX-2) and signaling pathways ... -
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C
(2005-07-22)Clostridium perfringens phospholipase C (Cp-PLC), also called alpha-toxin, is the major virulence factor in the pathogenesis of gas gangrene. Previously, a cellular UDP-Glc deficiency was related with a hypersensitivity ... -
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements
(2017-01)The antimicrobial resistance (AMR) rates and levels recorded for Clostridium difficile are on the rise. This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. ... -
A Comparison between a Relational Database and a Graph Database in the context of a Personalized Cancer Treatment Application
(2016)This paper presents a performance comparison between a relational database (implemented in MySQL) and a graph database (implemented in Neo4j). Unlike traditional benchmarks, this comparison is made in the context of a real ... -
A comparison of bio-inspired optimization methodologies applied to the tuning of industrial controllers
(2016-11-09)A comparison of different bio-inspired methods is presented for the problem of tuning the parameters of a PID industrial controller for second order plus time delay plants. The compared algorithms are representative of ... -
A Comparison of four Methods to Evaluate the Butterfly Abundance. Using a Tropical Community
(Journal of the Lepidopterists' Society 45(3), 1991, 241-243, 1991-03-18)In recent years. several transect methods to evaluate the abundance of butterflies have been proposed (Pollard, E. 1977, Biol. Conserv. 12:115—134; Feltwell, 3. 1982. Proc. Trans. Br. Entomol. Nat. Hist. Soc. 15:17—24). ... -
A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus
(1997-04)Therapeutic antisera against Micrurus nigrocinctus venom were tested for protection against lethality, as well as for inhibition of the nicotinic acetylcholine receptor (AchR)-binding and neutralization of phospholipase ... -
A constant area monolayer method to assess optimal lipid packing for lipolysis tested with several secreted phospholipases A2
(2015-10)We present an analysis of lipid monolayer hydrolysis at a constant area to assess the optimal lateral surface pressure value (Πopt) and thus, the surface packing density of the lipid, at which the activity of a given ... -
A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning enriched rats
(2009-01-30)Our previous work has shown that male Sprague–Dawley rats reared in social isolation, standard housing and environmental enrichment differ in their spontaneous open-field activity and in some neurobehavioral depressive-like ... -
A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu
(1992)Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also ... -
A geographical sampling method for surveys of mosquito larvae in an urban area using high-resolution satellite imagery
(2008-06-01)Entomological surveys in urban areas are often biased by selecting houses or locations with known high vector densities. A sampling strategy was developed for Puntarenas, Costa Rica, using high-resolution satellite imagery. ... -
A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways
(2011-07)We investigated the ability of the sPLA(2), known as MT-III, isolated from the viperid snake Bothrops asper, to induce LB formation in macrophages and the major cellular signaling pathways involved in this process. The ...