Now showing items 1-10 of 22
Menopause, A Universal Female Experience: Lessons from Mexico and Central America
(Current Women’s Health Reviews 4(1), 3-8, 2008)
In Mexico and Central America, women typically experience menopause up to 10 years earlier than their U.S. counterparts. This may be due in part to numerous pregnancies, long periods of lactation, poor nutrition, extreme ...
Synthesis of Iodinated Naphthoquinones Using Morpholine-Iodine Complex
(Synthetic Communications Vol. 34, No. 18, pp. 3389–3397, 2004, 2004)
The efficient synthesis of 2‐hydroxy‐3‐iodo‐1,4‐naphthoquinone (3), 2‐amino‐3‐iodo‐1,4‐naphthoquinone (4), and 2‐iodo‐1,4‐naphthoquinone (5) have been developed using the parent naphthoquinone in combination with the ...
Efficient syntheses of streptocarpone and (±)-a-dunnione
An efficient divergent synthesis of both streptocarpone and racemic α-dunnione from lawsone are described. A one-pot, formal [3+2] cyclization to form a furanonaphthoquinone directly provided a common intermediate.
Mastering analytical challenges for the characterization of pentacyclic triterpene mono- and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS
Pentacyclic triterpene mono- and diesters have been isolated from Calendula officinalis flowers. GC–MS, APCI-Exactive Orbitrap HR-MS and NMR allowed to identify the triterpene skeleton in various samples (different triterpene ...
Pristine but metal-rich Río Sucio (Dirty River) is dominated by Gallionella and other iron-sulfur oxidizing microbes
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes ...
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
Light Reflection by Cuticles of Chrysina Jewel Scarabs: Optical Measurements, Morphology Characterization, and Theoretical Modeling
Cuticles of some Chrysina scarabs are characterized by flat, graded, and twisted structures of nanosized chitin fibrils. As inferred from SEM images, each species has its own spatial period or pitch P which is dependent ...
Metals in coastal mollusks of Costa Rica
Metales en moluscos costeros de Costa Rica
The input of contaminants to coastal ecosystems is a global problem on the rise. Data on metal pollution from tropical sites is often lacking and pilot surveys are urgently needed to provide a general framework to estimate ...
Leaf and flower essential oil compositions of Gliricidia sepium (Fabaceae) from Costa Rica
Gliricidia is a small genus of flowering plants in the Fabaceae family. Gliricidia sepium is a multipurpose tree native to Mesoamerica and possibly northern South America. The chemical composition of the hydrodistilled ...