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Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom
Piratoxins (PrTX) I and III are phospholipases A2 (PLA2s) or PLA2 homologue myotoxins isolated from Bothrops pirajai snake venom, which also induce myonecrosis, bactericidal activity against Escherichia coli, disruption ...
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ...
A review of Bioinformatics training applied to research in Molecular Medicine, Agriculture and Biodiversity in Costa Rica and Central America
(Briefings in Bioinformatics, 14(5): 661-670, 2013-04-13)
Today, Bioinformatics has become a scientific discipline with great relevance for the Molecular Biosciences and for the Omics sciences in general. Although developed countries have progressed with large strides in ...
DNase activity in Costa Rican crotaline snake venoms: quantification of activity and identification of electrophoretic variants.
DNase activity of Costa Rican crotaline snake venoms from the genera Bothrops, Crotalus and Lachesis was quantified by an enzymodiffusion method on agarose/DNA gels containing ethidium bromide. The reaction is detected as ...
Post-exercise Rehydration: Potassium-rich Drinks vs. Water and a Sports Drink
Rehidratación post-ejercicio: bebidas con alto contenido de potasio vs. agua y una bebida deportiva
Fluid retention, thirst quenching, tolerance, and palatability of different drinks were assessed. On four different days, 12 healthy, physically active volunteers (24.4 ± 3.2 years old, 74.75 ± 11.36 kg body mass (mean ± ...
Anemia de células falciformes
(Gaceta Médica de Costa Rica, vol. 8, n. 1, enero-junio, 2006, 2006)
La enfermedad de células falciformes es un término usado para describir un grupo de desórdenes autosómicos recesivos, caracterizados por producción de hemoglobina anormal.
Prevalencia de Fasciola hepatica y pérdidas económicas asociadas al decomiso de hígados en tres mataderos de clase A de Costa Rica
Para estimar la prevalencia anual y mensual de Fasciola hepatica y las pérdidas económicas anuales asociadas al decomiso de hígados por presencia del parásito, se analizaron los registros del Ministerio de Agricultura ...
Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica
(J Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782., 2011)
We sought to identify cognitive phenotypes for family/genetic studies of successful cognitive aging (SCA; maintaining intact cognitive functioning while living to late old age).We administered a battery of neuropsychological ...
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper
A hemorrhagic metalloproteinase, named BaH4, was isolated from the venom of the snake Bothrops asper by a combination of ion-exchange chromatography on DEAE-Sepharose and gel filtration on Sephacryl S-200. BaH4 is a 69 kDa ...