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First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis 

Lomonte, Bruno; Mora Obando, Diana; Fernández Ulate, Julián; Sanz, Libia; Pla Ferrer, Davinia; Gutiérrez, José María; Calvete Chornet, Juan José (Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits of ...

Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels 

Moreira Carmona, Lisela; Borkow, Gadi; Ovadia, Michael; Gutiérrez, José María (1994-08)
The pathological changes induced in capillaries by BaH1, a hemorrhagic metalloproteinase isolated from the venom of Bothrops asper, were studied after i.m. injection in mouse gastrocnemius. Hemorrhage was observed ...

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors 

Cintra Francischinelli, Mariana; Pizzo, Paola; Rodrigues Simioni, Lea; Ponce Soto, Luis Alberto; Rossetto, O.; Lomonte, Bruno; Gutiérrez, José María; Pozzan, T.; Montecucco, Cesare (2009-04-17)
Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 ...
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Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves 

Hernández, Rosario; Cabalceta, Carmen; Saravia Otten, Patricia; Chaves, Alessandra; Gutiérrez, José María; Rucavado Romero, Alexandra (PLoS ONE 6(5): e19834, 2011-05-24)
Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes ...
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A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu 

Dos Santos, María Cristina; Gonçalves, Luís Roberto de Camargo; Fortes Dias, Consuelo L.; Cury, Yara; Gutiérrez, José María; Furtado, María de Fátima (1992)
Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also ...

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management 

Calvete Chornet, Juan José; Borges, Adolfo; Segura Ruiz, Álvaro; Flores Díaz, Marietta; Alape Girón, Alberto; Gutiérrez, José María; Diez, Nardy; De Sousa, Leonardo; Kiriakos, Demetrio; Sánchez, Eladio; Faks, José G.; Escolano, José; Sanz, Libia (2009-03-06)
The taxonomic status of the medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela, which has been classified as Bothrops colombiensis, remains incertae cedis. To help resolving this question, ...

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions 

León Montero, Guillermo; Monge Monge, María; Rojas Umaña, Ermila; Lomonte, Bruno; Gutiérrez, José María (2001-06)
Whole IgG and F(ab′)2 equine-derived polyvalent (Crotalinae) antivenoms, prepared from the same batch of hyperimmune plasma, were compared in terms of neutralization of the lethal and defibrinating activities induced by ...
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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming 

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Alape Girón, Alberto; Flores Díaz, Marietta; Sanz, Libia; Angulo Ugalde, Yamileth; Calvete Chornet, Juan José (2009-03-06)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...
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Cambios en el patrón electroforético del veneno de cascabela muda (Lachesis muta stenophrys) durante el almacenamiento bajo diferentes condiciones 

Gené, José Antonio; Lomonte, Bruno; Gutiérrez, José María; Cerdas Fallas, Luis (1985)
Liquid and lyophilized samples of Lachesis muta venom were stored at different temperatures and for different periods of time, and analyzed by polyacrylamide gel electrophoresis (PAGE) and immunoelectrophoresis. Only slight ...

Autocatalytic acylation of phospholipase-like myotoxins 

Pedersen, J. Z.; Lomonte, Bruno; Massoud, R.; Gubensek, F.; Gutiérrez, José María; Rufini, Stefano (1995-04)
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are ...
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Gutiérrez, José María (421)
Lomonte, Bruno (180)Rucavado Romero, Alexandra (64)Calvete Chornet, Juan José (57)León Montero, Guillermo (53)Angulo Ugalde, Yamileth (46)Sanz, Libia (43)Herrera Vega, María (36)Rojas Céspedes, Gustavo (36)Escalante Muñoz, Teresa (33)... View MoreTypeinfo:eu-repo/semantics/article (407)Artículo científico (398)info:eu-repo/semantics/bookPart (9)Capítulo de libro (5)Contribución a publicación periódica (2)info:eu-repo/semantics/contributionToPeriodical (2)info:eu-repo/semantics/publishedVersion (2)info:eu-repo/semantics/book (1)info:eu-repo/semantics/other (1)info:eu-repo/semantics/preprint (1)... View MoreProcedenceVicerrectoría de Investigación (420)Vicerrectoría de Docencia (32)... View MoreHas File(s)Yes (419)No (2)

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Universidad de Costa Rica