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Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica
(2004)
To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors ...
Adipose tissue biomarkers of fatty acid intake
(2002)
The use of biomarkers to assess dietary intake has increased dramatically in the past few years (1-7). Biomarkers may provide a more accurate and objective measure of long-term intake than dietary questionnaires provide ...
The Type of Oil Used for Cooking Is Associated with the Risk of Nonfatal Acute Myocardial Infarction in Costa Rica
(2005)
Palm oil and soybean oil are the 2 most widely used cooking oils in the world. Palm oil is consumed mainly in developing countries, where morbidity and mortality due to cardiovascular disease (CVD) are on the rise. Although ...
Fasting Whole Blood as a Biomarker of Essential Fatty Acid Intake in Epidemiologic Studies: Comparison with Adipose Tissue and Plasma
(2005)
Biomarkers could provide a more accurate measure of long-term intake than questionnaires. Adipose tissue is considered the best indicator of long-term essential fatty acid intake, but other tissues may prove equally valid. ...
Decreased Consumption of Dried Mature Beans Is Positively Associated with Urbanization and Nonfatal Acute Myocardial Infarction
(2005)
Legumes may protect against myocardial infarction (MI). The objective of this study was to determine whether consumption of dried mature beans (referred to as beans), the main legume in Latin America, is associated with ...
Transmission disequilibrium test (TDT) for case–control studies
(2004)
Genetic association, case–control studies are becoming a major instrument in the attempt to identify disease susceptibility markers of complex diseases. However, a major drawback of population-based studies of genetic ...
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
(2004)
There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ...
Effect of Apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica
(2007)
We assessed the effect of APOE polymorphisms−491 A/T, C112R (APOE*4), and R158C (APOE*2) and saturated fat intake on plasma lipid levels and risk of myocardial infarction (MI) in 1,927 case subjects and 1,927 population-based ...
The relation between trans fatty acid levels and increased risk of myocardial infarction does not hold at lower levels of trans fatty acids in the costa rican food supply
(2006)
Data on the effects of recent industrial modifications that reduced the trans fatty acid (TFA) content in food supplies are scarce. In this study, incident cases (n = 1797) of a first nonfatal myocardial infarction (MI) ...
Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults
(2007)
Arachidonic acid, a precursor to a series of inflammatory mediators, may contribute to the development of insulin resistance. We examined the association between adipose tissue arachidonic acid and the metabolic syndrome ...