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Venom, venomics, antivenomics 

Calvete Chornet, Juan José; Sanz, Libia; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María (2009)
Venoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, ...

An overview of Lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Calderón Fuentes, Leonel (2003)
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p. piscivorus [J. Biol. Chem. 259 (1984) ...
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Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom 

Murakami, Mário T.; Melo, Cristiane C.; Angulo Ugalde, Yamileth; Lomonte, Bruno; Arni, Raghuvir K. (2006)
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss ...

Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect 

Lomonte, Bruno; Pizarro Cerdá, Javier; Angulo Ugalde, Yamileth; Gorvel, Jean Pierre; Moreno Robles, Edgardo (1999)
Myotoxin II is a group II Lys49 phospholipase A2 (PLA2) isolated from the venom of the snake Bothrops asper. Previous studies on a synthetic peptide derived from its heparin-binding, cationic/hydrophobic sequence 115^129 ...

Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region 

Santamaría Quesada, Carlos Manuel; Larios Ramos, Silda; Angulo Ugalde, Yamileth; Pizarro Cerdá, Javier; Gorvel, Jean Pierre; Moreno Robles, Edgardo; Lomonte, Bruno (2005)
A short peptide derived from the C-terminal region of Bothrops asper myotoxin II, a Lys49 phospholipase A2 (PLA2), was previously found to reproduce the bactericidal activity of its parent molecule. In this study, a panel ...

Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A2 homologue 

Angulo Ugalde, Yamileth; Olamendi Portugal, Timoteo; Alape Girón, Alberto; Possani, Lourival D.; Lomonte, Bruno (2002)
In order to analyze its structure–function relationships, the complete amino acid sequence of myotoxin II from Atropoides (Bothrops) nummifer from Costa Rica was determined. This toxin is a Lys49-type phospholipase A2 ...

Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A2 from Bothrops asper snake venom 

Angulo Ugalde, Yamileth; Núñez, Carlos E.; Lizano González, Sergio; Soares, Andreimar Martins; Lomonte, Bruno (2001)
Myotoxic class II phospholipases A2 from snake venoms can be divided into Asp49 and Lys49 types. The latter, including Bothrops asper myotoxin II, exert membrane damage despite lacking catalytic activity. A heparin-binding, ...
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Método para la producción de formulaciones inyectables de productos proteicos hemoderivados y productos obtenidos utilizando dicho método 

Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; León Montero, Guillermo; Angulo Ugalde, Yamileth; Villalta Arrieta, Mauren; Herrera Vega, María (2011-04-08)
The invention relates to a method for producing injectable pharmaceutical formulations of blood-derived protein materials, including the steps of fractioning the source material in a polymer/salt aqueous two-phasesystem ...
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Angulo Ugalde, Yamileth (68)
Lomonte, Bruno (59)Gutiérrez, José María (46)Calvete Chornet, Juan José (23)Sanz, Libia (18)Fernández Ulate, Julián (10)León Montero, Guillermo (10)Alape Girón, Alberto (7)Rucavado Romero, Alexandra (7)Herrera Vega, María (5)... View MoreTypeinfo:eu-repo/semantics/article (67)Artículo científico (65)info:eu-repo/semantics/patent (1)ProcedenceVicerrectoría de Investigación (68)Vicerrectoría de Docencia (19)... View MoreHas File(s)Yes (67)No (1)

  • Repositorios universitarios

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  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica