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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming 

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Alape Girón, Alberto; Flores Díaz, Marietta; Sanz, Libia; Angulo Ugalde, Yamileth; Calvete Chornet, Juan José (2009-03-06)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...

The C-terminal region of a Lys49 myotoxin mediates Ca2þ influx in C2C12 myotubes 

Cintra Francischinelli, Mariana; Pizzo, Paola; Angulo Ugalde, Yamileth; Gutiérrez, José María; Montecucco, Cesare; Lomonte, Bruno (2010-02)
Myotoxins are abundant components of snake venoms, being a significant public health problem worldwide. Among them, Lys49 phospholipase A2 homologue myotoxins cause extensive necrosis in skeletal muscle tissue. Their ...
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Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: Report of a workshop 

Gutiérrez, José María; Fan, Hui Wen; Silvera, Carmen L.M.; Angulo Ugalde, Yamileth (2009-05)
The issues of antivenom stability and distribution, and the training of health staff in the correct use of antivenoms in Latin America were discussed in a workshop held at Instituto Clodomiro Picado, Costa Rica, in September ...

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus 

Angulo Ugalde, Yamileth; Castro Godínez, Adriana; Lomonte, Bruno; Rucavado Romero, Alexandra; Fernández Ulate, Julián; Calvete Chornet, Juan José; Gutiérrez, José María (2014-12)
Four disintegrins were isolated from the venoms of the Central American viperid snakes Atropoides mexicanus (atropoimin), Bothrops asper (bothrasperin), Cerrophidion sasai (sasaimin), and Crotalus simus (simusmin). ...

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties 

Lizano González, Sergio; Angulo Ugalde, Yamileth; Lomonte, Bruno; Fox, Jay W.; Lambeau, Gérard; Lazdunski, Michel; Gutiérrez, José María (2000-03-15)
Myotoxic phospholipases A2 (PLA2s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), ...
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Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii 

Lomonte, Bruno; Escolano, José; Fernández Ulate, Julián; Sanz, Libia; Angulo Ugalde, Yamileth; Gutiérrez, José María; Calvete Chornet, Juan José (2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...

Myotoxic phospholipases A2 in Bothrops snake venoms: Effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu 

Andrião Escarso, Silvia H.; Soares, Andreimar Martins; Rodrigues, Veridiana M.; Angulo Ugalde, Yamileth; Díaz Oreiro, Cecilia; Lomonte, Bruno; Gutiérrez, José María; Giglio, José Roberto (2000-08)
Venoms from eight Bothrops spp. were fractionated by ion-exchange chromatography on CM-Sepharose at pH 8.0 for the purification of myotoxins. Chromatographic profiles showed differences regarding myotoxic components among ...

Phospholipase A2 enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis 

Bustillo, Soledad; García Denegri, María Emilia; Gay, Carolina; Van de Velde, Andrea C.; Acosta, Ofelia; Angulo Ugalde, Yamileth; Lomonte, Bruno; Gutiérrez, José María; Leiva, Laura (2015-10-05)
Microvessel disruption leading to hemorrhage stands among the most dangerous consequences of envenomings by snakes of the family Viperidae. A PIII metalloproteinase (SVMP), balteragin, purified from the venom of the snake ...

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Rufini, Stefano; Cho, Wonhwa; Giglio, José Roberto; Ohno, Motoroni; Daniele, José Julían; Geoghegan, Patricia; Gutiérrez, José María (1999-01)
A rapid in vitro cytolytic effect of some myotoxic phospholipases A2 (PLA2s) isolated from the venoms of Viperidae snakes has been previously described. This study was undertaken to investigate if cytolytic activity is a ...

The Phospholipase A2 Homologues of Snake Venoms: Biological Activities and Their Possible Adaptive Roles 

Lomonte, Bruno; Angulo Ugalde, Yamileth; Sasa Marín, Mahmood; Gutiérrez, José María (2009)
A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA2 homologues. Among ...
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Angulo Ugalde, Yamileth (67)
Lomonte, Bruno (59)Gutiérrez, José María (46)Calvete Chornet, Juan José (23)Sanz, Libia (18)Fernández Ulate, Julián (10)León Montero, Guillermo (9)Alape Girón, Alberto (7)Rucavado Romero, Alexandra (7)Sasa Marín, Mahmood (5)... View MoreTypeinfo:eu-repo/semantics/article (67)Artículo científico (65)ProcedenceVicerrectoría de Investigación (67)Vicerrectoría de Docencia (19)... View MoreHas File(s)
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  • Repositorios universitarios

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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
Universidad de Costa Rica