Microbiología
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Transfección mediante vehículos génicos basados enhidroxiapatita: eficacia y efectos sobre el tráfico intracelular
(2025)La hidroxiapatita (HAp), Ca10(PO4)6(OH)2, es un mineral miembro de las apatitas con una razón Ca/P de 1,67. Es el principal componente mineral de los huesos en los vertebrados y posee una serie de características de interés ... -
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
(2019)Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation ... -
Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: comparative characterization and synergism between Asp49 and Lys49 variants
(2019)Bothrops diporus, previously considered a subspecies of the B. neuwiedi complex, is a medically relevant viperid in Northeastern Argentina. The venom of this species causes local tissue damage characterized by ... -
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes are ... -
New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America
(2019)Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species within this genus are endemic to the Americas, and are distributed from southeastern United States to ... -
Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica
(2019)The genus Porthidium includes nine pitviper species inhabiting Mexico, Central America, and northern South America. Porthidium porrasi is a species endemic to the Southwest of Costa Rica, for which no information on ... -
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
(2019)A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and neutralization ... -
Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro
(2019)non-buthid venoms, for which knowledge is scarce. In this work, we characterized the venom of a Diplocentridae species, Didymocentrus krausi, a small fossorial scorpion that inhabits the Tropical Dry Forest of Central ... -
Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin
(2019)Venoms of the three species of Ophryacus (O. sphenophrys, O. smaragdinus, and O. undulatus), a viperid genus endemic to Mexico, were analyzed for the first time in the present work. The three venoms lacked procoagulant ... -
Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens
(2019)Actinoporins constitute a unique class of pore-forming toxins found in sea anemones that being secreted as soluble monomers are able to bind and permeabilize membranes leading to cell death. The interest in these proteins ... -
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
(2019)A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering ... -
Distribución de subtipos de rhinovirus en niños atendidos en los meses de abril, mayo, junio, setiembre y octubre del 2014 en el Hospital Nacional de Niños y su asociación con el desarrollo de patologías respiratorias
(2020)Las infecciones del tracto respiratorio constituyen el principal motivo de consulta a los servicios de emergencias en todo el mundo, generando gastos millonarios en atención médica, así como en la pérdida de días laborales ... -
Analysis of mutational dynamics at the DMPK (CTG)n locus identifies saliva as a suitable DNA sample source for genetic analysis in myotonic dystrophy type 1
(2019-05)Genotype-to-phenotype correlation studies in myotonic dystrophy type 1 (DM1) have been confounded by the age-dependent, tissue-specific and expansion-biased features of somatic mosaicism of the expanded CTG repeat. Previously, ... -
Low-cost internal controls for detection of Giardia cysts in water samples
(2019-08)Giardia cysts stained with hot carbolfuchsin were used as internal controls in a concentration method for surface water samples. The morphological integrity of stained cysts and the stain's stability and intensity were ... -
Leucemia Mieloide Crónica Juvenil. A propósito de un caso
(2019-05-01)La leucemia Mieloide Crónica (LMC) es una neoplasia mieloproliferativa crónica, caracterizada por un gen de fusión t(9,22). El curso normal de la enfermedad consta de 3 fases: crónica, acelerada y blástica. En su gran ... -
Modificaciones proteicas inducidas por Brucella abortus 2308W en compartimentos intracelulares tempranos de macrófagos RAW 264.7
(2019)Brucella abortus es un patógeno intracelular bacteriano causante de la brucelosis bovina, una zoonosis desatendida de gran importancia mundial. Una vez entra a la célula hospedera B. abortus transita en un compartimento ... -
Caracterización proteómica y toxicológica del veneno de Crotalus pifanorum (viperidae) y evaluación de su uso como inmunógeno sobre la respuesta por anticuerpos contra co-inmunógenos y venenos de otros crótalos americanos
(2019)En Costa Rica se produce un antiveneno poliespecífico (PoliVal-ICP) usando como inmunógenos los venenos de las serpientes Bothrops asper, Crotalus simus y Lachesis stenophrys. Este antiveneno es capaz de neutralizar a la ... -
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)
(2019)The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030. In this context, ... -
Interacción de neutrófilos murinos con Brucella abortus
(2019-12)La brucelosis es una enfermedad zoonótica con distribución mundial. La enfermedad se caracteriza por ocasionar fiebre ondulante en humanos y abortos en animales domésticos como vacas, ovejas, cabras, cerdos y perros. ... -
ENSO‐Influenced Drought Drives Methane Flux Dynamics in a Tropical Wet Forest Soil
(2019)Global atmospheric methane growth rates have wildly fluctuated over the past three decades, which may be driven by the proportion of tropical land surface saturated by water. The El Niño/Southern Oscillation Event (ENSO) ...
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