• Determinación del Dímero D en pacientes con anticoagulante lúpico 

  Salazar Sánchez, Lizbeth; Jiménez Bonilla, Rafael; Holst Schumacher, Ileana; Madrigal, Fernando; Fonsecaz, Jorge (1997)

  La determinación del dímero D es de gran utilidad para establecer el diagnóstico de trombosis venosa profunda; sin embargo, en los pacientes que presentan anticoagulante lúpico su hallazgo e importancia todavía no ha sido ...

• A geographical sampling strategy for field surveys in an urban area using high-resolution satellite imagery 

  Troyo Rodríguez, Adriana; Fuller, Douglas O.; Calderón Arguedas, Ólger; Beier, John C. (2006-11)

  Field evaluations for studying the epidemiology of vector-borne diseases like dengue in urban areas are often restricted to selection of households and buildings for field surveys. Therefore, the resulting sampling frame ...

• Evaluation of predictive maps for Aedes aegypti larval habitats in two urban areas of Costa Rica 

  Troyo Rodríguez, Adriana; Calderón Arguedas, Ólger; Avendaño López, Adrián; Mora Pineda, Geovanny; Beier, John C.; Fuller, Douglas O. (2011-12)

  The abundance of Aedes aegypti can be associated with urban structure and tree cover, which conceals and protects containers. The purpose of this study was to create and evaluate predictive maps for Ae. Aegypti larval ...

• Epidemiological characterization of incident cases of Rickettsia infection in rural areas of Urabá region, Colombia 

  Quintero Vélez, Juan Carlos; Aguirre Acevedo, Daniel Camilo; Rodas González, Juan David; Arboleda, Margarita; Troyo Rodríguez, Adriana; Vega Aguilar, Francisco; Osorio Quintero, Lisardo; Rojas Arbeláez, Carlos (2018-10-31)

  Introduction Most of the studies related to rickettsial infection in Colombia are cross-sectional because of the challenge in conducting prospective studies on infectious disease that may have a difficult diagnosis. Although ...

• Biological and proteolytic variation in the venom of Crotalus scutulatus scutulatus from Mexico 

  Borja, Miguel; Neri Castro, Edgar; Castañeda Gaytán, Gamaliel; Strickland, Jason L.; Parkinson, Christopher L.; Castañeda Gaytán, Juan; Ponce López, Roberto; Lomonte, Bruno; Olvera Rodríguez, Alejandro; Alagón Cano, Alejandro; Pérez Morales, Rebeca (2018-01)

  Rattlesnake venoms may be classified according to the presence/absence and relative abundance of the neurotoxic phospholipases A2s (PLA2s), such as Mojave toxin, and snake venom metalloproteinases (SVMPs). In Mexico, ...

• Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profile of hemolytic and non-hemolytic isoforms 

  Fernández Montes de Oca, María Laura; Lomonte, Bruno; Yunes Quartino, Pablo J.; Arce Bejarano, Ruth; Fernández Ulate, Julián; Camacho, Luis F.; Gutiérrez, José María; Kuemmel, Daniel; Fidelio, Gerardo Daniel (2018-04)

  A unique feature of the venom of Micrurus fulvius (Eastern coral snake) is its ability to induce severe intravascular hemolysis in particular species, such as dogs or mice. This effect was previously shown to be induced ...

• Pros and cons of different therapeutic antibody formats for recombinant antivenom development 

  Laustsen, Andreas Hougaard; Gutiérrez, José María; Knudsen, Cecilie; Johansen, Kristoffer H.; Bermúdez Méndez, Erick; Cerni, Felipe A.; Jürgensen, Jonas A.; Ledsgaard, Line; Martos Esteban, Andrea; Øhlenschlæger, Mia; Pus, Urska; Andersen, Mikael Rørdam; Lomonte, Bruno; Engmark, Mikael Gerling; Pucca, Manuela Berto (2018-05)

  Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being ...

• Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus 

  Sánchez Brenes, Andrés; Herrera Vega, María; Villalta Arrieta, Mauren; Solano, Daniela; Segura Ruíz, Álvaro; Lomonte, Bruno; Gutiérrez, José María; León Montero, Guillermo; Vargas Arroyo, Mariángela (2018-06)

  The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom ...

• Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms 

  Gutiérrez, José María; Rucavado, Alexandra; Escalante Muñoz, Teresa; Herrera Arias, Cristina; Fernández Ulate, Julián; Lomonte, Bruno; Fox, Jay W. (2018-06)

  Snakebite envenoming by viperid species, and by some elapids, is characterized by a complex pattern of tissue damage at the anatomical site of venom injection. In severe cases, tissue destruction may be so extensive as ...

• A myotoxic Lys49 phospholipase A2-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina 

  de Roodt, Adolfo Rafael; Fernández Ulate, Julián; Solano, Daniela; Lomonte, Bruno (2018-04-27)

  Bothrops cotiara is a pitviper found in Southeastern Brazil and, scarcely, in the Misiones province of Argentina. In contrast to considerable information available on the venom of the Brazilian snake population, that of ...

• MipLAAO, a new L-amino acid oxidase from the redtail coral snake, Micrurus mipartitus 

  Rey Suárez, Paola; Acosta, Cristian; Torres Lamus, Uday Daniel; Saldarriaga Córdoba, Mónica Marı́a; Lomonte, Bruno; Núñez Rangel, Vitelbina (2018-06-08)

  L-amino acid oxidases (LAAOs) are ubiquitous enzymes in nature. Bioactivities described for these enzymes include apoptosis induction, edema formation, induction or inhibition of platelet aggregation, as well as antiviral, ...

• A snake venom secreted phospholipase A2 induces foam cell formation depending on the activation of factors involved in lipid homeostasis 

  Leiguez, Elbio; do Nascimento Viana, Mariana; Hideki Matsubara, Márcio; Fernandes, Cristina Maria; Giannotti, Karina Cristina; Gutiérrez, José María; Lomonte, Bruno; Teixeira, Catarina de Fátima (2018-06)

  MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid ...

• Las creencias machistas de los docentes de educación física y su relación con la obesidad en los estudiantes 

  Núñez Rivas, Hilda Patricia; Holst Schumacher, Ileana; Campos Saborío, Natalia (2019-01)

  El personal docente de Educación Física debe poner en práctica propuestas de cambio que rompan con la reproducción de una cultura machista y discriminatoria y abran espacios a nuevas generaciones de estudiantes más solidarias, ...

• Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins 

  Turkington, Hannah L.; Juozapaitis, Mindaugas; Tsolakos, Nikos; Corrales Aguilar, Eugenia; Schwemmle, Martín; Hale, Benjamín G. (2018-02-12)

  Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins ...

• A novel pentameric phospholipase A2 myotoxin (PophPLA2) from the venom of the pit viper Porthidium ophryomegas 

  Vindas González, Julio; Carrera Rengifo, Yarina; Lomonte, Bruno; Gutiérrez, José María; Calvete Chornet, Juan José; Sanz, Libia; Fernández Ulate, Julián (2018-06-07)

  The first toxin isolated from the venomous pit viper Porthidiumophryomegas is a basic pentameric phospholipase A2 (PophPLA2). Elucidation of its amino acid sequence showed that it belongs to the group IIA of secreted ...

• A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors 

  Corrales Aguilar, Eugenia; Trilling, Mirko; Reinhard, Henrike; Mercé Maldonado, Eva; Widera, Marek; Schaal, Heiner; Zimmermann, Albert; Mandelboim, Ofer; Hengel, Hartmut (2013-01-31)

  IgG responses are crucial in antiviral defence and instrumental for the serodiagnosis of infections. Fcγ receptors (FcγRs), which recognize the Fc-part of IgG, differ regarding their IgG binding affinity, IgG subclass ...

• Dengue Virus Infection of Primary Human Smooth Muscle Cells 

  Arias Arias, Jorge Luis; Vega Aguilar, Francisco; Corrales Aguilar, Eugenia; Hun Opfer, Laya R.; Loría Masis, Gilbert David; Mora Rodríguez, Rodrigo (2018-11-05)

  Dengue virus (DENV) infection of humans is presently the most important arthropod-borne viral global threat, for which no suitable or reliable animal model exists. Reports addressing the effect of DENV on vascular components ...

• Prevalencia de la mutación c677t en la enzima MTHFR en adultos del Valle Central de Costa Rica 

  Holst Schumacher, Ileana (2005-11)

  En Costa Rica la enfermedad cardiovascular (ECV) representa la primera causa de muerte desde la década de 1970 razón por la cual el estudio de los factores de riesgo asociados a esta patología resulta de gran importancia. ...

• Evaluación de tres métodos de laboratorio para la cuantificación de hierro sérico y capacidad total de fijación de hierro 

  Quintana Guzmán, Eugenia María; Holst Schumacher, Ileana (1996)

  Se evaluaron tres métodos de laboratorio para la determinación de hierro sérico (FeS) y capacidad total de fijación de hierro sérico (CTFFeS): el método de Beale (método de referencia) y un método comercial tanto con sus ...

• Cuidado con la obesidad infantil y juvenil 

  Holst Schumacher, Ileana (2007-10)

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