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Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium
Acute muscle tissue damage, myonecrosis, is a typical consequence of envenomations by snakes of the family Viperidae. Catalytically-inactive Lys49 phospholipase A2 homologues are abundant myotoxic components in viperid ...
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...
The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America
(PLoS Neglected Tropical Diseases, 2011-07-26)
The general strategy used by high-income countries to address global health challenges in low- and middle-income countries (LMICs) relies heavily on short-term strategies designed to diminish the burden of diseases afflicting ...