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Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: Evidence of rapid plasma membrane damage and a dual role for extracellular calcium
Acute muscle tissue damage, myonecrosis, is a typical consequence of envenomations by snakes of the family Viperidae. Catalytically-inactive Lys49 phospholipase A2 homologues are abundant myotoxic components in viperid ...
Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis
We report the proteomic characterization of the venoms of two closely related pit vipers of the genus Lachesis, L. muta (South American Bushmaster) and L. stenophrys (Central American Bushmaster), and compare the toxin ...
Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper
A serine proteinase with thrombin-like activity was isolated from the venom of the Central American pit viper Bothrops asper. Isolation was performed by a combination of affinity chromatography on aminobenzamidine-Sepharose ...
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...
Increased Infectivity of Staphylococcus aureus in an Experimental Model of Snake Venom–Induced Tissue Damage
Soft-tissue infection is commonly found in patients bitten by Latin American Bothrops snakes. Staphylococcus aureus, which is not present in the mouth of the snake, is frequently isolated from these infections. The effects ...
Systemic and local myotoxicity induced by snake venom group II phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue
The patterns of myotoxicity induced in mice by crotoxin, crotoxin B and a Lys49 phospholipase A2 (PLA2) homologue were compared. Lys49 PLA2-induced local myotoxicity is reflected by creatine kinase (CK) loss in injected ...
Desarrollo de las universidades públicas de Latinoamérica: una visión alternativa al modelo economicista de rentabilidad
Development of public universities in latin america: an alternative perspective to the economicist model of profitability
(Universidad de Costa Rica, 2011)
Los modelos ideológico-económicos preponderantes en Latinoamérica en las últimas décadas han impuesto un concepto estrecho de rentabilidad económica en muchas áreas de la sociedad, incluyendo aquellas en las que se ...
Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper)
Two myotoxins isolated from B. asper (myotoxin II) and B. nummifer (myotoxin I) snake venoms have been crystallized and their diffraction properties are described. These myotoxins are phospholipase A2 variants which lack ...
Dr. Clodomiro Picado Twight (1887-1944)
Semblanza de Clodomiro Picado Twight, quien jugó un papel central en el desarrollo inicial de varias ramas de la ciencia en Costa Rica. Su formación académica se inició en el Colegio San Luis Gonzaga, en Cartago, donde ...