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Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose
(2010)
We report the proteomic characterization and biological activities of the venom of the black-speckled palm pitviper, Bothriechis nigroviridis, a neotropical arboreal pitviper from Costa Rica. In marked contrast to other ...
Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain
(2010-07-26)
Myotoxins play a major role in the pathogenesis of the envenomations caused by snake bites in large parts of the world where this is a very relevant public health problem. We show here that two myotoxins that are major ...
Efecto del suero antiofídico sobre la actividad hemolítica del complemento humano (in vitro) y de conejo (in vitro e in vivo).
(1989)
En el presente trabajo se investigó el efecto del suero antiofídico polivalente, producido en Costa Rica, sobre la actividad hemolítica (CH50) del complemento sérico humano (in vitro) y de conejo (in vitro e in vivo). ...
Utilidad de los péptidos sintéticos en estudios de estructura-función e identificación de epitopos en toxinas
(Bruno Lomonte. (2014). Utilidad de los péptidos sintéticos en estudios de estructura-función e identificación de epitopos en toxinas. Cuba: RED BIOTOX-CYTED. pp.71-80, 2014)
Los péptidos sintéticos han ganado un lugar relevante dentro de la “caja de herramientas” de la investigación biomédica actual. Las técnicas de síntesis automatizada y el costo decreciente de los procesos, unidas a mejoras ...
A structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms
(Biochimica et Biophysica Acta - Proteins and Proteomics 1844(12):2265-2276, 2014-12)
Envenomation via snakebites is an important public health problem in many tropical and subtropical countries that, in addition to mortality, can result in permanent sequelae as a consequence of local tissue damage, which ...
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
(2003-05)
The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ...
Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies
(1992)
The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported. The monoclonal antibodies, MAb-3 and Mab-4, recognize different ...
Neutralization of coral snake Micrurus nigrocinctus venom by a monovalent antivenom
(1991)
The neutralizing ability of a monovalent anti-Micrurus nigrocinctus (coral snake) antivenom produced in Costa Rica was tested against the lethal, myotoxic and phospholipase A2 activities of homologous venom. In addition, ...
Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms
(1991)
An enzyme-immunoassay (EIA) for the quantitation of antibodies against myotoxins present in the venoms of Bothrops asper (Costa Rica), B. atrox (Colombia) and B. moojeni (Brazil), was developed. This EIA was utilized for ...
Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2
(1991)
A basic, dimeric myotoxic protein, myotoxin II, purified from Bothrops asper venom has a similar molecular weight and is immunologically cross-reactive with antibodies raised to previously isolated B. asper phospholipases ...