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First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis 

Lomonte, Bruno; Mora Obando, Diana; Fernández Ulate, Julián; Sanz, Libia; Pla Ferrer, Davinia; Gutiérrez, José María; Calvete Chornet, Juan José (Toxicon vol 93:144–154, 2015-01)
Bothriechis nigroviridis is an arboreal Neotropical pitviper found in Costa Rica and Panam a. A previous proteomic profiling of its venom revealed the presence of proteins with homology to the A and B subunits of ...

Calcium imaging of muscle cells treated with snake myotoxins reveals toxin synergism and presence of acceptors 

Cintra Francischinelli, Mariana; Pizzo, Paola; Rodrigues Simioni, Lea; Ponce Soto, Luis Alberto; Rossetto, O.; Lomonte, Bruno; Gutiérrez, José María; Pozzan, T.; Montecucco, Cesare (2009-04-17)
Snake myotoxins have a great impact on human health worldwide. Most of them adopt a phospholipase A2 fold and occur in two forms which often co-exist in the same venom: the Asp49 toxins hydrolyse phospholipids, whilst Lys49 ...
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Phospholipases a2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms 

Ghazaryan, Narine A.; Ghulikyan, Lusine; Kishmiryan, Arsen; Andreeva, Tatyana V.; Utkin, Yuri N.; Tsetlin, Victor I.; Lomonte, Bruno; Ayvazyan, Naira M. (Biochimica et Biophysica Acta - Biomembranes vol 1848: 463–468, 2015-02)
We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed ...
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N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils 

Mora Cartín, Ricardo; Chacón Díaz, Carlos; Gutiérrez Jiménez, Cristina; Gurdián Murillo, Stephany; Lomonte, Bruno; Chaves Olarte, Esteban; Barquero Calvo, Elías; Moreno Robles, Edgardo (2016-06)
Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions 

León Montero, Guillermo; Monge Monge, María; Rojas Umaña, Ermila; Lomonte, Bruno; Gutiérrez, José María (2001-06)
Whole IgG and F(ab′)2 equine-derived polyvalent (Crotalinae) antivenoms, prepared from the same batch of hyperimmune plasma, were compared in terms of neutralization of the lethal and defibrinating activities induced by ...
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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming 

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Alape Girón, Alberto; Flores Díaz, Marietta; Sanz, Libia; Angulo Ugalde, Yamileth; Calvete Chornet, Juan José (2009-03-06)
Snakebite envenoming represents a neglected tropical disease that has a heavy public health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at increasing antivenom production and ...

Edema-forming activity of bushmaster (Lachesis muta stenophrys) and Central American rattlesnake (Crotalus durissus durissus) venoms and neutralization by a polyvalent antivenom 

Lomonte, Bruno (1985)
The edema effect induced in mice by venoms of Crotalus durissus durissus and Lachesis muta stenophrys was studied . Minimum edema-forming doses were 11 and 5 ug, respectively . Edema developed very rapidly after injections ...

Production and partial characterization of monoclonal antibodies to Bothrops asper (terciopelo) myotoxin 

Lomonte, Bruno; Kahan, Lawrence (1988)
Seven murine monoclonal antibodies against Bothrops aspen myotoxin were produced and partially characterized. They revealed the presence of at least four cross-reacting basic components in crude venom, with a common subunit ...
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Cambios en el patrón electroforético del veneno de cascabela muda (Lachesis muta stenophrys) durante el almacenamiento bajo diferentes condiciones 

Gené, José Antonio; Lomonte, Bruno; Gutiérrez, José María; Cerdas Fallas, Luis (1985)
Liquid and lyophilized samples of Lachesis muta venom were stored at different temperatures and for different periods of time, and analyzed by polyacrylamide gel electrophoresis (PAGE) and immunoelectrophoresis. Only slight ...

Autocatalytic acylation of phospholipase-like myotoxins 

Pedersen, J. Z.; Lomonte, Bruno; Massoud, R.; Gubensek, F.; Gutiérrez, José María; Rufini, Stefano (1995-04)
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are ...
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Lomonte, Bruno (291)
Gutiérrez, José María (174)Angulo Ugalde, Yamileth (58)Calvete Chornet, Juan José (40)Fernández Ulate, Julián (32)Sanz, Libia (31)Rucavado Romero, Alexandra (22)León Montero, Guillermo (17)Rojas Céspedes, Gustavo (15)Alape Girón, Alberto (14)... View MoreTypeinfo:eu-repo/semantics/article (277)Artículo científico (248)info:eu-repo/semantics/bookPart (8)Capítulo de libro (7)Contribución a publicación periódica (3)info:eu-repo/semantics/contributionToPeriodical (3)info:eu-repo/semantics/doctoralThesis (1)info:eu-repo/semantics/other (1)info:eu-repo/semantics/preprint (1)Preprint (1)... View MoreProcedenceVicerrectoría de Investigación (291)Vicerrectoría de Docencia (48)... View MoreHas File(s)Yes (291)

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