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Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab0)2 and whole IgG antivenoms 

Herrera Vega, María; de Cássia de O. Collaço, Rita; Villalta Arrieta, Mauren; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Wright, Christine E.; Paiva, Owen K.; Matainaho, Teatulohi; Jensen, Simon D.; León Montero, Guillermo; Williams, David J.; Rodrigues Simioni, Lea; Gutiérrez, José María (2016-01-22)
The neuromuscular junction activity of Oxyuranus scutellatus venom and its presynaptic neurotoxin, taipoxin, and their neutralization by two antivenoms were examined in mouse phrenic nerve-diaphragm preparations. The action ...

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms 

Sánchez Brenes, Andrés; Coto Porras, Jorge; Segura Ruiz, Álvaro; Vargas Arroyo, Mariángela; Solano Trejos, María Gabriela; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Gutiérrez, José María (2015-12-15)
Two antivenoms prepared by using Echis ocellatus, Bitis arietans and Naja nigricollis venoms from different locations in sub-Saharan Africa were compared for their neutralizing ability. Both antivenoms were similarly ...

Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa 

Calvete Chornet, Juan José; Cid, Pedro; Sanz, Libia; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Herrera Vega, María; León Montero, Guillermo; Harrison, Robert A.; Durfa, Nandul; Nasidi, Abdulsalami; Theakston, R. David G.; Warrell, David A.; Gutiérrez, José María (2010)
The immunoreactivity of EchiTAb-Plus-ICP, an antivenom developed for the treatment of snakebite envenoming in sub-Saharan Africa, to venoms of seven Echis and Bitis species, was assessed by “antivenomics.” This proteomic ...
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La situación de los antivenenos liofilizados en América Latina: Aspectos tecnológicos y de salud pública
Freeze-dried antivenoms in latin america: technological and public health considerations 

Gutiérrez, José María; Herrera Vega, María; León Montero, Guillermo (2012)
La administración parenteral de antivenenos constituye el elemento central en la terapia de los envenenamientos por mordeduras o picaduras de animales ponzoñosos. En América Latina existen laboratorios productores de ...

Assessing the preclinical efficacy of antivenoms: From the lethality neutralization assay to antivenomics 

Gutiérrez, José María; Solano Trejos, María Gabriela; Pla Ferrer, Davinia; Herrera Vega, María; Segura Ruiz, Álvaro; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Sanz, Libia; Lomonte, Bruno; Calvete Chornet, Juan José; León Montero, Guillermo (2013-07)
The assessment of the capacity of antivenoms to neutralize the lethal activity of snake venoms is the gold standard in the preclinical analysis of antivenom efficacy, and is routinely performed by manufacturers and quality ...

Role of the animal model on the pharmacokinetics of equine-derived antivenoms 

Rojas Araya, Alicia; Vargas Arroyo, Mariángela; Ramírez Arguedas, Nils Antonio; Estrada Umaña, Ricardo; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Gómez Argüello, Aarón; Gutiérrez, José María; León Montero, Guillermo (2013-08)
Antivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of ...

Immune Response Towards Snake Venoms 

León Montero, Guillermo; Sánchez Céspedes, Laura Vanessa; Hernández, Andrés; Villalta Arrieta, Mauren; Herrera Vega, María; Segura Ruiz, Álvaro; Estrada Umaña, Ricardo; Gutiérrez, José María (2011)
The immune response involves a complex repertoire of innate and adaptive responses to foreign agents in the organism. The present review focuses on the immune response to snake venoms, including those occurring in snakebite ...

Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms 

Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Vargas Arroyo, Mariángela; Uscanga Reynell, Alfredo; Ponce de León Rosales, Samuel; Jiménez Corona, María Eugenia; Reta Mares, José Francisco; Gutiérrez, José María; León Montero, Guillermo (2012-01)
Bothrops asper is the species that induces the highest incidence of snakebite envenomation in southern Mexico, Central America and parts of northern South America. The intraspecies variability in HPLC profile and ...

Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches 

Gutiérrez, José María; Sanz, Libia; Flores Díaz, Marietta; Figueroa, Lucía; Madrigal Villalobos, Marvin; Herrera Vega, María; Villalta Arrieta, Mauren; León Montero, Guillermo; Estrada Umaña, Ricardo; Borges, Adolfo; Alape Girón, Alberto; Calvete Chornet, Juan José (2010-10-21)
Intraspecific snake venom variations have implications in the preparation of venom pools for the generation of antivenoms. The impact of such variation in the cross-reactivity of antivenoms against Bothrops asper venom was ...
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Preclinical evaluation of caprylic-acid fractionated IgG antivenom for the treatment of taipan (Oxyuranus scutellatus) envneoming in Papua New Guinea 

Vargas Arroyo, Mariángela; Segura Ruiz, Álvaro; Herrera Vega, María; Villalta Arrieta, Mauren; Estrada Umaña, Ricardo; Cerdas Solís, Maykel; Paiva, Owen K.; Matainaho, Teatulohi; Jensen, Simon D.; Winkel, Kenneth D.; León Montero, Guillermo; Gutiérrez, José María; Williams, David J. (PLoS Neglected Tropical Diseases 5 (5) e1144, 2011-05-17)
Background: Snake bite is a common medical emergency in Papua New Guinea (PNG). The taipan, Oxyuranus scutellatus, inflicts a large number of bites that, in the absence of antivenom therapy, result in high mortality. ...
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Herrera Vega, María (42)
León Montero, Guillermo (38)Gutiérrez, José María (36)Segura Ruiz, Álvaro (33)Villalta Arrieta, Mauren (29)Vargas Arroyo, Mariángela (27)Estrada Umaña, Ricardo (10)Calvete Chornet, Juan José (9)Gómez Argüello, Aarón (6)Lomonte, Bruno (6)... View MoreTypeartículo científico (40)capítulo de libro (1)patente (1)ProcedenceVicerrectoría de Investigación (42)Vicerrectoría de Docencia (4)... View MoreHas File(s)Yes (39)No (3)

  • Repositorios universitarios

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