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Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus

Angulo Ugalde, Yamileth; Castro Godínez, Adriana; Lomonte, Bruno; Rucavado Romero, Alexandra; Fernández Ulate, Julián; Calvete Chornet, Juan José; Gutiérrez, José María (2014-12)

Four disintegrins were isolated from the venoms of the Central American viperid snakes Atropoides mexicanus (atropoimin), Bothrops asper (bothrasperin), Cerrophidion sasai (sasaimin), and Crotalus simus (simusmin). ...

Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica

Angulo Ugalde, Yamileth; Chaves Olarte, Esteban; Rucavado Romero, Alexandra; Gutiérrez, José María; Lomonte, Bruno; Alape Girón, Alberto (1997-03)

A new myotoxic phospholipase A2was isolated from the venom of the arboreal snakeBothriechis schlegelii(formerlyBothrops schlegelii) from Costa Rica, by ion-exchange chromatography on CM-Sephadex.B. schlegeliimyotoxin I is ...

Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?

Gutiérrez, José María; Rucavado Romero, Alexandra; Escalante Muñoz, Teresa; Lomonte, Bruno; Angulo Ugalde, Yamileth; Fox, Jay W. (2010-01)

The study of snake venom-induced local tissue pathology has been predominantly based on experimental designs and concepts that view tissue alterations from a dichotomous, homogeneous and reductionist perspective. Experimental ...

Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations

Gutiérrez, José María; Lomonte, Bruno; León Montero, Guillermo; Rucavado Romero, Alexandra; Chaves Mora, Fernando; Angulo Ugalde, Yamileth (2007)

The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...

Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of a Heterologous Antivenom

Gutiérrez, José María; Sanz, Libia; Escolano, José; Fernández Ulate, Julián; Lomonte, Bruno; Angulo Ugalde, Yamileth; Rucavado Romero, Alexandra; Warrell, David A.; Calvete Chornet, Juan José (2008-10)

The venom proteomes of the snakes Bothrops caribbaeus and Bothrops lanceolatus, endemic to the Lesser Antillean islands of Saint Lucia and Martinique, respectively, were characterized by reversephase HPLC fractionation, ...

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice

Lopes Ferreira, Mónica; Núñez, Javier; Rucavado Romero, Alexandra; Farsky, Sandra H. P.; Lomonte, Bruno; Angulo Ugalde, Yamileth; Moura Da Silva, Ana M.; Gutiérrez, José María (2001-02)

Stings by Thalassophryne nattereri are responsible for envenomation of fishermen in north-eastern Brazil. Its venom induces prominent local tissue damage, characterized by pain, oedema and necrosis. The pathogenesis of ...