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Importance of mevalonate pathway lipids on the growth and survival of primary and metastatic gastric carcinoma cells
(2021)
Purpose: This preclinical study aims to determine the effect of drugs that alter isoprenoids and cholesterol metabolism in the homeostasis of gastric carcinoma cell lines in the search for new therapeutic targets for stomach ...
Mevalonate pathway as a novel target for the treatment of metastatic gastric cancer
(2020-10)
Gastric mucosa tumors may present as two distinct major entities: Diffuse and intestinal subtypes. There is no
standard treatment for advanced or metastatic gastric cancer. The mevalonate pathway and cholesterol homeostasis ...
Modelo de lógica difusa como alternativa para la evaluación de la satisfacción de usuarios del laboratorio clínico
(2014)
La calidad consiste en un conjunto de características propias de un producto a nivel de variabilidad y cumplimiento de los
requerimiento del cliente, el cual también incluye el cómo se brinda el servicio a éste. Una de ...
Occurrence of pathogenic microorganisms in small drinking-water systems in Costa Rica
(2022-02-03)
This study describes the quality of drinking water sampled over 2 years (2018 and 2019) from 20 ASADAS (Spanish acronym for Administrative
Associations for Water and Sewer Systems) in Costa Rica. The analysis included ...
Presence and potential distribution of malaria‑infected New World primates of Costa Rica
(2022-01-08)
Background: In South and Central America, Plasmodium malariae/Plasmodium brasilianum, Plasmodium vivax, Plas- modium simium, and Plasmodium falciparum has been reported in New World primates (NWP). Specifically in Costa ...
Alterations in common marmoset gut microbiome associated with duodenal strictures
(2022-03-28)
Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets (Callithrix jacchus). Despite standardized housing, diet and husbandry, a recently described gastrointestinal syndrome ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica
(2022-06)
Emerging mutations and genotypes of the SARS-CoV-2 virus, responsible for the COVID-19 pandemic, have been reported globally. In Costa Rica during the year 2020, a predominant genotype carrying the mutation T1117I in the ...
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease
(2022-03-15)
Chronic gastrointestinal (GI) diseases are the most common diseases in captive common marmosets. To understand the role of the microbiome in GI diseases, we characterized the gut microbiome of 91 healthy marmosets (303 ...
High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern
(2021)
SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and
therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We
tested therapeutic equine polyclonal antibodies (pAbs) ...