Medicina, ciencias biomédicas y salud pública
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Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
(2004)There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ... -
Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica
(2004)To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors ... -
Editorial: limitações das leituras de temperatura temporal (testa) como método de triagem para COVID-19
(2020-06-25)Com o avanço contínuo da pandemia de Covid-19, muitos países estão em processo de reabertura de escolas, igrejas e empresas. Em um esforço para rastrear indivíduos potencialmente infectados, a temperatura da artéria temporal ... -
Voz experta: El problema de usar las mediciones de la temperatura corporal en la frente como método de tamizaje para el COVID-19
(2020-06-25)En estos tiempos de la pandemia por la enfermedad COVID-19, muchos países han iniciado el proceso de reapertura de escuelas, iglesias y negocios. Para limitar el riesgo de contagio, una de las medidas consiste en detectar ... -
Intake of trans fatty acids and low-density lipoprotein size in a Costa Rican population
(2003)Intervention studies show that dietary composition altered low-density lipoprotein (LDL) particle size, but population studies are scarce, and the potential effects of trans fatty acids (FA) on LDL size are unknown. Trans ... -
High 18:2 trans fatty acids are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults
(2003)Trans-fatty acid intake is associated with coronary heart disease (CHD), but the atherogenic potential of individual trans-fatty acids (FA) from partially hydrogenated oils (18:1 and 18:2) or meat and dairy products (16:1 ... -
APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica
(2005)Genetic variation in the APOC3 and APOA5 genes has been associated with plasma triglyceride concentrations and may affect the risk of myocardial infarction (MI). To assess whether APOC3/A5 haplotypes are associated with ... -
GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
(2007)Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ... -
Does genetic variation in the Δ6-desaturase promoter modify the association between α-linolenic acid and the prevalence of metabolic syndrome?
(2009)Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ... -
Conjugated linoleic acid in adipose tissue and risk of myocardial infarction
(2010)Despite the high saturated fat content of dairy products, no clear association between dairy product intake and risk of myocardial infarction (MI) has been observed. Dairy products are the main source of conjugated linoleic ... -
Planificación familiar
(1994)En este capítulo se presentan los resultados de la encuesta referentes al conocimiento, difusión y uso de la planificación familiar en Costa Rica. En el análisis se aborda el uso en el pasado, la adopción por vez primera ... -
Association between hepatic lipase -514 C/T promoter polymorphism and myocardial infarction is modified by history of hypercholesterolemia and waist circumference
(2009)Background and aims: To examine whether the association between the 514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist ... -
Adipose tissue biomarkers of fatty acid intake
(2002)The use of biomarkers to assess dietary intake has increased dramatically in the past few years (1-7). Biomarkers may provide a more accurate and objective measure of long-term intake than dietary questionnaires provide ... -
Immune effects of mesenchymal stem cells: Implications for Charcot–Marie–Tooth disease
(2008-07)Mesenchymal stem cell (MSC) therapy is the most clinically advanced form of cell therapy, second to hematopoietic stem cell transplants. To date, MSC have been used for immune modulation in conditions such as Graft Versus ... -
Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety
(2017-04-04)Psychosocial stress contributes to the development of anxiety and depression. Recent clinical studies have reported increased inflammatory leukocytes in circulation of individuals with stress-related psychiatric disorders. ... -
Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults
(2006)Cardiovascular disease (CVD) has become an important public health problem in transition countries in Latin America (Medina and Kaempffer, 2000; Cubillos-Garzón et al., 2004; Ventura and Mehra, 2004; World HealthOrganization, ... -
Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica
(2016)Intellectual disability is a highly heterogeneous disease that affects the central nervous system and impairs patients’ ability to function independently. Despite multiples genes involved in the etiology of disease, most ... -
GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations
(2016)Objective: Psychosocial stress is associated with altered immunity, anxiety, and depression. Repeated social defeat (RSD), a model of social stress, triggers egress of inflammatory myeloid progenitor cells (MPCs; ... -
Protocolo de analgesia para el parto del Hospital Calderón Guardia
(2019-09)El siguiente protocolo se basa en la literatura más reciente sobre analgesia utilizada en la labor del parto, además se realiza un breve repaso en la fisiología, anatomía y conceptos básicos implicados en el dolor del ... -
Análisis de costos y viabilidad de la utilización de la medición de microglobulina alfa-1-placentaria en el abordaje de la sospecha amenaza de parto pretérmino en el Hospital de las Mujeres Dr. Adolfo Carit Eva (HOMACE), enero-junio 2019 como propuesta para la toma de decisiones en salud pública
(2020)Los análisis económicos constituyen una herramienta para la toma de decisiones en el ámbito gerencial de la Salud Pública, pues cuando las decisiones de unos repercuten directamente sobre la vida o salud de otros, la ...
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