Medicina, ciencias biomédicas y salud pública
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α-Linolenic acid, Δ6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction
(2007)Background:Δ6-Desaturase (FADS2) is the rate-limiting step in the polyunsaturated fatty acid (PUFA) biosynthetic pathway. Objective: The aim was to test whether the common deletion [T/-] in the promoter of FADS2 affects ... -
Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
(2007)Background: Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population. ... -
Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction
(2008)Background: Plasma apolipoprotein (apo) C-III strongly predicts myocardial infarction (MI) and directly activates atherogenic processes in vascular cells. Genetic variation in the insulin response element of the APOC3 ... -
Triggers of Nonfatal Myocardial Infarction in Costa Rica: Heavy Physical Exertion, Sexual Activity, and Infection
(2007)Purpose There are no data for factors that could trigger myocardial infarction (MI) in the context of lifestyles in developing countries. Methods Using a case–crossover design, we assessed the effect of heavy physical ... -
Microsomal epoxide hydrolase genotype and risk of myocardial infarction
(2007)DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). Microsomal epoxide hydrolase (EPHX1) is involved in the metabolism of tobacco smoke mutagens and an ... -
Nonfatal acute myocardial infarction in Costa Rica: modifiable risk factors, population-attributable risks, and adherence to dietary guidelines
(2007)Disability and mortality resulting from cardiovascular disease (CVD) are on the rise in many developing countries, partly because of the nutritional transition and westernization of lifestyles. Developing countries account ... -
Adipose tissue arachidonic acid and the metabolic syndrome in Costa Rican adults
(2007)Arachidonic acid, a precursor to a series of inflammatory mediators, may contribute to the development of insulin resistance. We examined the association between adipose tissue arachidonic acid and the metabolic syndrome ... -
The relation between trans fatty acid levels and increased risk of myocardial infarction does not hold at lower levels of trans fatty acids in the costa rican food supply
(2006)Data on the effects of recent industrial modifications that reduced the trans fatty acid (TFA) content in food supplies are scarce. In this study, incident cases (n = 1797) of a first nonfatal myocardial infarction (MI) ... -
Fasting Whole Blood as a Biomarker of Essential Fatty Acid Intake in Epidemiologic Studies: Comparison with Adipose Tissue and Plasma
(2005)Biomarkers could provide a more accurate measure of long-term intake than questionnaires. Adipose tissue is considered the best indicator of long-term essential fatty acid intake, but other tissues may prove equally valid. ... -
The Type of Oil Used for Cooking Is Associated with the Risk of Nonfatal Acute Myocardial Infarction in Costa Rica
(2005)Palm oil and soybean oil are the 2 most widely used cooking oils in the world. Palm oil is consumed mainly in developing countries, where morbidity and mortality due to cardiovascular disease (CVD) are on the rise. Although ... -
Decreased Consumption of Dried Mature Beans Is Positively Associated with Urbanization and Nonfatal Acute Myocardial Infarction
(2005)Legumes may protect against myocardial infarction (MI). The objective of this study was to determine whether consumption of dried mature beans (referred to as beans), the main legume in Latin America, is associated with ... -
Transmission disequilibrium test (TDT) for case–control studies
(2004)Genetic association, case–control studies are becoming a major instrument in the attempt to identify disease susceptibility markers of complex diseases. However, a major drawback of population-based studies of genetic ... -
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
(2004)There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ... -
Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica
(2004)To assess common variants of the LPL gene that could influence susceptibility to myocardial infarction (MI), we assessed three functional single-nucleotide polymorphisms (SNPs), D9N, N291S, and S447X, in 1,321 survivors ... -
Editorial: limitações das leituras de temperatura temporal (testa) como método de triagem para COVID-19
(2020-06-25)Com o avanço contínuo da pandemia de Covid-19, muitos países estão em processo de reabertura de escolas, igrejas e empresas. Em um esforço para rastrear indivíduos potencialmente infectados, a temperatura da artéria temporal ... -
Voz experta: El problema de usar las mediciones de la temperatura corporal en la frente como método de tamizaje para el COVID-19
(2020-06-25)En estos tiempos de la pandemia por la enfermedad COVID-19, muchos países han iniciado el proceso de reapertura de escuelas, iglesias y negocios. Para limitar el riesgo de contagio, una de las medidas consiste en detectar ... -
Intake of trans fatty acids and low-density lipoprotein size in a Costa Rican population
(2003)Intervention studies show that dietary composition altered low-density lipoprotein (LDL) particle size, but population studies are scarce, and the potential effects of trans fatty acids (FA) on LDL size are unknown. Trans ... -
High 18:2 trans fatty acids are associated with increased risk of nonfatal acute myocardial infarction in Costa Rican adults
(2003)Trans-fatty acid intake is associated with coronary heart disease (CHD), but the atherogenic potential of individual trans-fatty acids (FA) from partially hydrogenated oils (18:1 and 18:2) or meat and dairy products (16:1 ... -
APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica
(2005)Genetic variation in the APOC3 and APOA5 genes has been associated with plasma triglyceride concentrations and may affect the risk of myocardial infarction (MI). To assess whether APOC3/A5 haplotypes are associated with ... -
GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
(2007)Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ...
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