Now showing items 1-20 of 38

    • A schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations study 

      Escamilla, Michael; Hare, Elizabeth; Dassori, Albana; Peralta, Juan Manuel; Ontiveros, Humberto; Nicolini Sánchez, José Humberto; Medina, Rolando; Mendoza Rodríguez, Ricardo; Muñoz, Rodrigo; Almasy, Laura; Raventós Vorst, Henriette; Jerez, Álvaro (Am J Psychiatry 2009;166:442-449, 2009-02-02)
      The present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed ...
    • Absolute pitch in Costa Rica: Distribution of pitch identification ability and implications for its genetic basis 

      Chavarría Soley, Gabriela (2016-08-10)
      Absolute pitch is the unusual ability to recognize a pitch without an external reference. The current view is that both environmental and genetic factors are involved in the acquisition of the trait. In the present study, ...
    • Adjudicating Neurocognitive Endophenotypes for Schizophrenia 

      Burk, Gary; Estrada, Jose; Peralta, Juan Manuel; Meyenberg, Naxhielli; Barrett, Jennifer; Nicolini Sánchez, José Humberto; Escamilla, Michael; Glahn, David C.; Almasy, Laura; Blangero, John; Pereira Castro, Mariana; Raventós Vorst, Henriette (American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 144B:242–249 (2007), 2007-03-05)
      Although genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that genes predisposing to schizophrenia may be ...
    • Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population 

      Campos Sánchez, Rebeca; Raventós Vorst, Henriette; Barrantes Mesén, Ramiro (Human Biology Open Access Pre-Prints. Paper 34., 2013-10-09)
      Study for the first time a random sample from all regions of the country with AIMS (Ancestry Informative Markers) to address the individual and regional admixture proportions. A sample of 160 male individuals was screened ...
    • Association of Apolipoprotein E-e4 and Dementia Declines with Age 

      Valerio Aguilar, Daniel; Raventós Vorst, Henriette; Schmeidler, James; Beeri, Michal S.; Mora Villalobos, Lara; Bolaños Palmieri, Patricia; Carrión Baralt, José R.; Fornaguera Trías, Jaime; Silverman, Jeremy M. (2014-10)
      To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). In both case-control ...
    • Call for a change in research funding priorities: the example of mental health in Costa Rica 

      Contreras Rojas, Javier; Raventós Vorst, Henriette; Rodríguez Arauz, Gloriana; Leandro Rojas, Mauricio (2014)
      The World Health Organization (WHO) Mental Health Action Plan 2013-2020 urges its Member States to strengthen leadership in mental health, ensure mental and social health interventions in community-based settings, promote ...
    • Caracterización clínica de familias costarricenses con trastorno afectivo bipolar 

      Contreras Rojas, Javier; Raventós Vorst, Henriette; Contreras Rojas, Javier (2014-12)
      Justificación y objetivos: la heterogeneidad clínica del trastorno afectivo bipolar tipo I constituye uno de los principales desafíos en el diagnóstico de dicha enfermedad. Se necesitan múltiples fuentes de información ...
    • Caracterización de un grupo de pacientes con esquizofrenia en el Valle Central de Costa Rica 

      Montero Vega, Ana Patricia; Dassori, Albana; Escamilla, Michael; Raventós Vorst, Henriette; Contreras Rojas, Javier (AMC, vol 50 (3), julio-setiembre 2008, 2008)
      La esquizofrenia es una enfermedad crónica con importantes repercusiones sociales que afecta al 1% de la población mundial. Se describe las características de la esquizofrenia en una muestra de pacientes del Valle Central ...
    • Cefalea en racimos 

      Van Vliet, J. A.; Ferrani, M. D.; Peralta, Juan Manuel; Raventós Vorst, Henriette; Chaves Sell, Franz (Acta Médica Costarricense, Julio-Setiembre 2003, vol 45 (3) 97-101, 2003)
      La cefalea en racimos (CR) o “neuralgia de Horton”, es un tipo relativamente raro de cefalea que se presenta en forma de ataques y cuya severidad le ha dado el nombre de “dolor de cabeza suicida”. Debido a que la CR es una ...
    • Desempeño de la prueba “Mini-Mental State Examination” en personas adultas mayores sin deterioro cognitivo 

      Mora Villalobos, Lara; Contreras Rojas, Javier; Valerio Aguilar, Daniel; Raventós Vorst, Henriette; Schnaider Beeri, Michal; Silverman, Jeremy M. (2017)
      Objetivo: Establecer datos normativos de la prueba MMSE estratificada por edad y escolaridad en personas adultas mayores costarricenses sin deterioro cognitivo, identificar los ítems que presentan mayor dificultad en ...
    • Diagnosis of Schizophrenia in Latino Populations. A Comparison of Direct Interview and Consensus Based Multi-Source Methods 

      Dassori, Albana; Medina, Rolando; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Muñoz, Rodrigo; Escamilla, Michael; Contreras Rojas, Javier; Raventós Vorst, Henriette (Journal of Nervous and Mental Disease 2009;197: 530–535, 2009-07)
      We determined the rates of agreement between diagnoses, using the Diagnostic Interview for Genetic Studies (DIGS) and diagnoses arrived at, using additional sources of information, to establish whether there are differences ...
    • Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations 

      Zavala, Juan Manuel; Dassori, Albana; Escamilla, Michael; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Jerez, Álvaro; Contreras Rojas, Javier; Ramírez, Mercedes; Contreras, Salvador; Flores, Deborah; Leach, Robin J.; Armas, Regina; González, S. D. (Translational Psychiatry (2013) 3, e265, 2013-05-28)
      Some of the most consistent findings have been in variants located in the ANK3 (ankyrin-G) gene located on chromosome 10q. Schultz et al.4 found that BP risk alleles in ANK3, rs9804190 and rs10994336, contributed ...
    • Foro sobre salud mental 2011, conclusiones y pasos futuros 

      Contreras Rojas, Javier; Raventós Vorst, Henriette (Acta médica costarricense Vol 55 (3), julio-setiembre 2013, 132-138, 2013-07)
      Antecedentes: la salud es un proceso social que tiene como fin el bienestar físico y mental del individuo a través de todas las etapas de su vida. A pesar de numerosos esfuerzos, en Costa Rica, el abordaje en salud mental ...
    • Genetic Structure Analysis of Three Hispanic Populations from Costa Rica, Mexico, and the Southwestern United States Using Y-Chromosome STR Markers and mtDNA Sequences 

      Silva de la Fuente, Sandra Maria; Escamilla, Michael; Ontiveros, Humberto; Mendoza Rodríguez, Ricardo; Muñoz, Rodrigo; Raventós Vorst, Henriette; Campos Sánchez, Rebeca; Barrantes Mesén, Ramiro (Human Biology, October 2006, v. 78, no. 5, pp. 551–563., 2006)
      Two hundred seventeen male subjects from Costa Rica, Mexico, and the Hispanic population of the southwestern United States were studied. Twelve Y-chromosome STRs and the HVSI sequence of the mtDNA were analyzed to ...
    • Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder 

      Hare, Elizabeth; Contreras Rojas, Javier; Flores, Deborah; Jerez, Álvaro; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Almasy, Laura; Escamilla, Michael; Raventós Vorst, Henriette (Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
      Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig Five personality factors and the ...
    • Genética de la esquizofrenia: avances en el estudio de genes candidatos 

      Pacheco, Adriana; Raventós Vorst, Henriette (Rev. biol. trop v.52 n.3, p. 467-473 sep. 2004, 2004)
      Genetics of Schizophrenia: advances in the study of candidate genes. Schizophrenia is one of the most severe mental disorders that affect 1% of the population worldwide. It is clear that both genetic and environmental ...
    • Heritability of Age of Onset of Psychosis in Schizophrenia 

      Hare, Elizabeth; Glahn, David C.; Dassori, Albana; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Medina, Rolando; Mendoza Rodríguez, Ricardo; Jerez, Álvaro; Muñoz, Rodrigo; Almasy, Laura; Escamilla, Michael (AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)
      Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...
    • Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica 

      Greenwood, Tiffany A.; Beeri, Michal S.; Schmeidler, James; Valerio Aguilar, Daniel; Raventós Vorst, Henriette; Mora Villalobos, Lara; Camacho, Karla; Carrión Baralt, José R.; Angelo, Gary; Almasy, Laura; Sano, Mary; Silverman, Jeremy M. (J Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782., 2011)
      We sought to identify cognitive phenotypes for family/genetic studies of successful cognitive aging (SCA; maintaining intact cognitive functioning while living to late old age).We administered a battery of neuropsychological ...
    • Heterozygous Loss-of-Function Variants in CYP1B1 Predispose to Primary Open-Angle Glaucoma 

      Passuto, Francesca; Chavarría Soley, Gabriela; Mardin, Christian Y.; Michels Rautenstrauss, Karin G.; Ingelman Sundberg, Magnus; Fernández Martínez, Lorena; Weber, Bernhard H. F.; Rautenstrauss, Bernd; Reis, André (2010-01)
      Purpose.: Although primary congenital glaucoma (PCG)–associated CYP1B1 mutations in the heterozygous state have been evaluated for association with primary open-angle glaucoma (POAG) in several small studies, their ...
    • High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees 

      Castri, Loredana; Barrantes Mesén, Ramiro; Pereira Reyes, Reinaldo; Luiselli, Donata; Pettener, Davide; Barbujani, Guido; Madrigal, Lorena; Meléndez Obando, Mauricio O.; Villegas Palma, Ramón; Raventós Vorst, Henriette (American Journal of Physical Anthropology 2012 July ; 148(3): 327–333., 2012-07)
      Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA (mtDNA) vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) ...