ABSTRACT: Objectives: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers ...

Studies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere ...

Objective: The study examined the relationship of self-rated health and self-rated economic situation with depressed mood, and life satisfaction as mediator of this relationship among older adults in Costa Rica. Method: A ...

Reliable data show that the Nicoyan region of Costa Rica is a hot spot of high longevity. A survival follow-up of 16,300 elderly Costa Ricans estimated a Nicoya death rate ratio (DRR) for males 1990–2011 of 0.80 (0.69–0.93 ...

We studied the relationships between blood pressure (BP), pulse pressure (PP) and cardiovascular (CV) death in older adults using data from 2346 participants enrolled in the Costa Rican CRELES study, mean age 76 years (s.d. ...

Objetivo. Valorar el impacto de la reforma del sector de la salud iniciada en Costa Rica en 1995 sobre la mortalidad de niños y adultos y la equidad en el acceso a los servicios de salud. Métodos. La reforma del sector ...

Background: Little is known about adult health and mortality relationships outside high-income nations, partly because few datasets have contained biomarker data in representative populations. Our objective is to ...

Telomere length has generated substantial interest as a potential predictor of aging- related diseases and mortality. Some studies have reported significant associations, but few have tested its ability to discriminate ...

Background: Although previous studies have indicated that performance assessments strongly predict future survival, few have evaluated the incremental value in the presence of controls for self-reported activity and mobility ...

La reforma del sector de la salud en Costa Rica, iniciada en 1995, no se llevó a cabo al mismo tiempo en todas las comunidades del país, sino que se aplicó paulatinamente en una especie de experimento natural, lo que ...