To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). In both case-control ...

Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and ...

Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig Five personality factors and the ...

Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...

This study attempted to replicate evidence for association of the Epsin 4 gene (which encodes enthoprotin, a protein involved in vesicular transport) to schizophrenia in a new sample of families segregating schizophrenia ...

Some of the most consistent findings have been in variants located in the ANK3 (ankyrin-G) gene located on chromosome 10q. Schultz et al.4 found that BP risk alleles in ANK3, rs9804190 and rs10994336, contributed ...

Primary-i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred in Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies at about age ...

Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events. Method: We evaluated whether ...

We determined the rates of agreement between diagnoses, using the Diagnostic Interview for Genetic Studies (DIGS) and diagnoses arrived at, using additional sources of information, to establish whether there are differences ...