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High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees
(American Journal of Physical Anthropology 2012 July ; 148(3): 327–333., 2012-07)
Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial
DNA (mtDNA) vary widely, depending on whether they are inferred from phylogenies (assuming
that molecular evolution is clock-like) ...
Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
(Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
Bipolar disorder (BPD) has been associated with variations in personality dimensions,
but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig
Five personality factors and the ...
Foro sobre salud mental 2011, conclusiones y pasos futuros
(Acta médica costarricense Vol 55 (3), julio-setiembre 2013, 132-138, 2013-07)
Antecedentes: la salud es un proceso social que tiene como fin el bienestar físico y mental del
individuo a través de todas las etapas de su vida. A pesar de numerosos esfuerzos, en Costa Rica, el
abordaje en salud mental ...
Genética de la esquizofrenia: avances en el estudio de genes candidatos
(Rev. biol. trop v.52 n.3, p. 467-473 sep. 2004, 2004)
Genetics of Schizophrenia: advances in the study of candidate genes. Schizophrenia is one of the
most severe mental disorders that affect 1% of the population worldwide. It is clear that both genetic and
environmental ...
Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica
(J Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782., 2011)
We sought to identify cognitive phenotypes for family/genetic studies of successful cognitive
aging (SCA; maintaining intact cognitive functioning while living to late old age).We
administered a battery of neuropsychological ...
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
(J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)
Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...
Identificación de genes causales y de susceptibilidad para enfermedades de herencia Mendeliana y compleja
Identification of Susceptibility and Causing Genes for Mendelian and Complex Diseases
(Acta médica costarricense Vol 51 (1), enero-marzo 2009, 2009-01)
Los factores genéticos participan en la etiología de la mayoría de las enfermedades comunes en
la población. Las enfermedades en las que participan factores genéticos pueden ser clasificadas
en varias categorías y de ...
Heritability of Age of Onset of Psychosis in Schizophrenia
(AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...
Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families
(Arch Gen Psychiatry. 2010;67(2):168-177, 2010-02-01)
Context: Although genetic influences on bipolar disorder
are well established, localization of genes that predispose
to the illness has proven difficult. Given that genes
predisposing to bipolar disorder may be transmitted ...
The serotonin transporter 5-HTTPR polymorphism is associated with current and lifetime depression in persons with chronic psychotic disorders
(Acta Psychiatr Scand 2009: 119: 117–127, 2009-01-11)
Objective: Variation in the serotonin transporter gene (SLC6A4)
promoter region has been shown to influence depression in persons
who have been exposed to a number of stressful life events.
Method: We evaluated whether ...