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Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in latinos: a family-based association study

Xu, Chun; Zavala, Juan Manuel; Armas, Regina; Contreras, Salvador; Dassori, Albana; Ontiveros Sánchez de la Barquera, Jose Alfonso; Nicolini Sánchez, José Humberto; Escamilla, Michael; Ramírez, Mercedes; Flores, Deborah; Jerez, Álvaro; Raventós Vorst, Henriette; González, Suzanne; Leach, Robin J. (Bipolar Disorders 2013: 15: 206–214, 2013-02-25)

Objectives: Through recent genome-wide association studies (GWASs), several groups have reported significant association between variants in the calcium channel, voltage-dependent, L-type, alpha 1C subunit (CACNA1C) and ...

Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica

Greenwood, Tiffany A.; Beeri, Michal S.; Schmeidler, James; Valerio Aguilar, Daniel; Raventós Vorst, Henriette; Mora Villalobos, Lara; Camacho, Karla; Carrión Baralt, José R.; Angelo, Gary; Almasy, Laura; Sano, Mary; Silverman, Jeremy M. (J Alzheimers Dis. 2011 ; 27(4): 897–907. doi:10.3233/JAD-2011-110782., 2011)

We sought to identify cognitive phenotypes for family/genetic studies of successful cognitive aging (SCA; maintaining intact cognitive functioning while living to late old age).We administered a battery of neuropsychological ...

In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation

Marballi, Ketan; Quiñones, Marlon; Jiménez, Fabio; Escamilla, Michael; Raventós Vorst, Henriette; Soto Bernardini, María Clara; Ahuja, Seema S.; Walss Bass, Consuelo (J Mol Med (Berl). 2010 November ; 88(11): 1133–1141, 2010-11)

Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune ...

Identificación de genes causales y de susceptibilidad para enfermedades de herencia Mendeliana y compleja
Identification of Susceptibility and Causing Genes for Mendelian and Complex Diseases

Rodríguez Porras, Luis; Raventós Vorst, Henriette (Acta médica costarricense Vol 51 (1), enero-marzo 2009, 2009-01)

Los factores genéticos participan en la etiología de la mayoría de las enfermedades comunes en la población. Las enfermedades en las que participan factores genéticos pueden ser clasificadas en varias categorías y de ...

Heritability of Age of Onset of Psychosis in Schizophrenia

Hare, Elizabeth; Glahn, David C.; Dassori, Albana; Raventós Vorst, Henriette; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Medina, Rolando; Mendoza Rodríguez, Ricardo; Jerez, Álvaro; Muñoz, Rodrigo; Almasy, Laura; Escamilla, Michael (AMERICAN JOURNAL OF MEDICAL GENETICS PART B, 2009-04)

Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due ...

Substance use disorder and schizophrenia: prevalence and sociodemographic characteristics in the Latin American population
Esquizofrenia y trastorno en el consumo de sustancias: prevalencia y características sociodemográficas en la población Latina

Jiménez Castro, Lorena; Raventós Vorst, Henriette; Escamilla, Michael (Actas Esp Psiquiatr 2011;39(2):123-30, 2011)

El interés por comprender la co-morbilidad de la esquizofrenia y el trastorno en el uso de sustancias, ha aumentado debido al incremento de este diagnóstico, a los efectos negativos observados en el sujeto y a los ...

High mitochondrial mutation rates estimated from deep-rooting Costa Rican pedigrees

Castri, Loredana; Barrantes Mesén, Ramiro; Pereira Reyes, Reinaldo; Luiselli, Donata; Pettener, Davide; Barbujani, Guido; Madrigal, Lorena; Meléndez Obando, Mauricio O.; Villegas Palma, Ramón; Raventós Vorst, Henriette (American Journal of Physical Anthropology 2012 July ; 148(3): 327–333., 2012-07)

Estimates of mutation rates for the noncoding hypervariable Region I (HVR-I) of mitochondrial DNA (mtDNA) vary widely, depending on whether they are inferred from phylogenies (assuming that molecular evolution is clock-like) ...

Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder

Hare, Elizabeth; Contreras Rojas, Javier; Flores, Deborah; Jerez, Álvaro; Nicolini Sánchez, José Humberto; Ontiveros Sánchez de la Barquera, Jose Alfonso; Almasy, Laura; Escamilla, Michael; Raventós Vorst, Henriette (Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)

Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig Five personality factors and the ...

Foro sobre salud mental 2011, conclusiones y pasos futuros

Contreras Rojas, Javier; Raventós Vorst, Henriette (Acta médica costarricense Vol 55 (3), julio-setiembre 2013, 132-138, 2013-07)

Antecedentes: la salud es un proceso social que tiene como fin el bienestar físico y mental del individuo a través de todas las etapas de su vida. A pesar de numerosos esfuerzos, en Costa Rica, el abordaje en salud mental ...

Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families

Glahn, David C.; Almasy, Laura; Barguil, Marcela; Hare, Elizabeth; Peralta, Juan Manuel; Kent, Jack; Dassori, Albana; Contreras Rojas, Javier; Pacheco, Adriana; Lanzargorta, Nuria; Nicolini Sánchez, José Humberto; Raventós Vorst, Henriette; Escamilla, Michael (Arch Gen Psychiatry. 2010;67(2):168-177, 2010-02-01)

Context: Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted ...