Now showing items 11-20 of 45
Asociación de trombofilia con mutaciones en el gen que codifica para el factor V, la protrombina y la metiltetrahidrofolato reductasa: descripción de dos casos familiares
Thrombophilia association with mutations in the gene encoding the V leiden factor, prothrombin and methyltetrahydrofolate reductase: description of two family cases
Las trombofilias son alteraciones del equilibrio homeostático, esto predispone a la formación de pequeños trombos a nivel venoso y raramente en las arterias. Las trombofilias se han clasificado en hereditarias y adquiridas ...
Profiling of WDR36 Missense Variants in German Patients with Glaucoma
PURPOSE. Mutations in WDR36 were recently reported in patients with adult-onset primary open-angle glaucoma (POAG). In this study, the prevalence of WDR36 variants was investigated in patients with glaucoma who were of ...
Absolute pitch in Costa Rica: Distribution of pitch identification ability and implications for its genetic basis
Absolute pitch is the unusual ability to recognize a pitch without an external reference. The current view is that both environmental and genetic factors are involved in the acquisition of the trait. In the present study, ...
Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents
Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The ...
Effect of an In Vitro Digestion on the Antioxidant Capacity of a Microfiltrated Blackberry Juice (Rubus adenotrichos)
The health benefits attributed to berries are largely dependent on their bioavailability. This study evaluated the antioxidant activity for different samples of blackberry juice submitted to an in vitro digestion. The HPLC ...
Sub-chronic administration of St. John’s wort reverses anxiety- and depressive-like behaviors induced by two different protocols of chronic stress
La administración sub-crónica de hierba de San Juan revierte las conductas de ansiedad y depresión inducidas por dos protocolos distintos de estrés crónico
Introduction. St. John’s wort (Hypericum perforatum, HP) is one of the most used herbal medicines. Here we investigated the putative antidepressive- and anxiolytic-like effects of HP, by using a well-validated rat model ...
Association of Apolipoprotein E-e4 and Dementia Declines with Age
To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample). In both case-control ...
Identification and Functional Characterization of CLCN1 Mutations Found in Nondystrophic Myotonia Patients
Mutations in the gene coding for the skeletal muscle Cl− channel (CLCN1) lead to dominant or recessive myotonia. Here, we identified and characterized CLCN1 mutations in Costa Rican patients, who had been clinically diagnosed ...
Behavioral and neurochemical characterization of maternal care effects on juvenile Sprague–Dawley rats
Maternal care represents a major constituent of early life environment and has the potential to modulate critical neurobehavioral responses to stress. The aim of the present study was to determine the effects of naturally ...
Age-dependent effects of environmental enrichment on spatial memory and neurochemistry
Although aging and environmental stimulation are well-known to affect cognitive abilities, the question of whether aging effects can be distinguished in already-mature adult rats has not been fully addressed. In the ...