Now showing items 1-10 of 27
Sub-chronic administration of St. John’s wort reverses anxiety- and depressive-like behaviors induced by two different protocols of chronic stress
La administración sub-crónica de hierba de San Juan revierte las conductas de ansiedad y depresión inducidas por dos protocolos distintos de estrés crónico
Introduction. St. John’s wort (Hypericum perforatum, HP) is one of the most used herbal medicines. Here we investigated the putative antidepressive- and anxiolytic-like effects of HP, by using a well-validated rat model ...
Automated Video-Image Analysis of Behavioral Asymmetries
The analysis of behavioral asymmetries is a widely employed approach to investigate behavior in relation to functions of the brain. Out of the repertory of presently available measures, turning behavior is probably the one ...
Behavioral indices of moderate nigrostriatal 6–hydroxydopamine lesion: a preclinical Parkinson's model.
Asymmetries in turning and scanning were investigated in rats with different degrees of neostriatal dopamine depletion after unilateral injections of 6-hydroxydopamine into the substantia nigra. Animals with severe lesions, ...
En busca de un modelo preclínico de la enfermedad de Parkinson. Segunda parte
En la Primera parte de este artículo, expuse muy brevemente, algunas de las características de la enfermedad del Parkinson y sobre todo lo difícil que ha sido a lo largo de la historia encontrar una terapéutica realmente ...
Behavioral asymmetries and recovery in rats with different degrees of unilateral striatal dopamine depletion
A detailed behavioral analysis during the first postoperative week was performed in rats which had sustained various degrees of unilateral neostriatal dopamine (DA) lesions by administration of the neurotoxin 6-hydroxydopamine ...
A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries
A video image analyzing system is presented which measures turning behavior, thigmotactic scanning and locomotion in rats. The system works by analyzing digitized video images obtained by a black/white video camera. Turning ...
Methylmercury increases S100B content in rat cerebrospinal fluid
S100B, a calcium binding protein physiologically produced and released by astrocytes, has been used as a peripheral marker of brain damage. Here, we investigated the effects of subcutaneous injections of methylmercury ...
Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum
Dawley rats were reared from weaning in either social isolation, standard laboratory conditions, or environmental enrichment. Open-field activity was assessed at postnatal days 37, 65, 93 and 107 and 1 h before the last ...
Un método simple para la recolección, extracción y medición de catecolaminas en orina de adultos mayores
A simple method to collect, extract and measure urinary catecholamines in elderly people
La medición de catecolaminas en orina ha sido utilizada tanto para diagnóstico como para la investigación. Este trabajo propone algunas modificaciones y condiciones estandarizadas para llevar a cabo la recolección ...
Factor analysis of Forced Swimming test, Sucrose Preference test and Open Field test on enriched, social and isolated reared rats
Developmental and social factors are known to play a crucial role in the pathogenesis of affective disorders. Although it has been demonstrated that early life aversive experiences can be a risk factor in the development ...