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Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
Background: Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population. ...
Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
There is growing evidence that DNA damage caused by mutagens found in tobacco smoke may contribute to the development of coronary heart disease (CHD). In order to bind to DNA many mutagens require metabolic activation by ...
GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are associated with protection against components of the metabolic syndrome, but the role of α-linolenic acid (ALA), the metabolic precursor of EPA and ...
Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction
ontext The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. ...