Now showing items 1-6 of 6

    • Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts 

      Cheng, Ken Chih-Chien; Cao, Shugeng; Raveh, Avi; MacArthur, Ryan; Dranchak, Patricia; Chlipala, George; Okoneski, Matthew T.; Guha, Rajarshi; Eastman, Richard T.; Yuan, Jing; Schultz, Pamela J.; Su, Xin-zhuan; Tamayo Castillo, Giselle; Matainaho, Teatulohi; Clardy, Jon; Sherman, David H.; Inglese, James (2015)
      Methods to identify the bioactive diversity within natural product extracts (NPEs) continue to evolve. NPEs constitute complex mixtures of chemical substances varying in structure, composition, and abundance. NPEs can ...
    • Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis 

      Sidhu, Alpa; Miller, Justin R.; Tripathi, Ashootosh; Garshott, Danielle M.; Brownell, Amy L.; Chiego, Daniel J.; Arevang, Carl Johan; Zeng, Qinghua; Jackson, Leah C.; Bechler, Shelby A.; Callaghan, Michael U.; Yoo, George H.; Sethi, Seema; Lin, Ho-Sheng; Callaghan, Joseph H.; Tamayo Castillo, Giselle; Sherman, David H.; Kaufman, Randal J.; Fribley, Andrew M. (2015)
      Oral squamous cell carcinoma (OSCC) is the most common cancer affecting the oral cavity, and US clinics will register about 30,000 new patients in 2015. Current treatment modalities include chemotherapy, surgery, and ...
    • Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway 

      Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng; Schultz, Pamela J.; Yim, Isaiah; McQuade, Thomas J.; Yu, Fengan; Arevang, Carl Johan; Mensah, Abraham Y.; Tamayo Castillo, Giselle; Xi, Chuanwu; Sherman, David H. (2016-02-16)
      Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix where they colonize to form a biofilm. This cellular superstructure can display increased resistance to antibiotics and ...
    • Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts 

      Cruz, Patricia G.; Fribley, Andrew M.; Miller, Justin R.; Larsen, Martha J.; Schultz, Pamela J.; Jacob, Renju T.; Tamayo Castillo, Giselle; Kaufman, Randal J.; Sherman, David H. (2015-07-06)
      As part of the International Cooperative Biodiversity Groups (ICBG) Program, we were interested in identifying biologically active unfolded protein response (UPR) inducing compounds from marine microorganisms isolated from ...
    • Selvamicin, an atypical antifungal polyene from two alternative genomic contexts 

      Van Arnam, Ethan B.; Ruzzini, Antonio C.; Sit, Clarissa Sau-Wei; Horn, Heidi A.; Pinto Tomás, Adrián A.; Currie, Cameron Robert; Clardy, Jon (2016-11-15)
      The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of antifungal compounds from these bacteria, we discovered selvamicin, an ...
    • The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling 

      De Ford, Christian; Heidersdorf, B.; Haun, F.; Merfort, Irmgard; Murillo Masís, Renato; Friedrich, T.; Borner, C. (2016-01-28)
      T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...