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Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder
(2016-02-09)
Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity ...
Sobre el genoma humano, la medicina personalizada y el sistema de seguridad social
(2016)
La promesa del proyecto del genoma humano (PGH) fue que iba a transformar radicalmente la práctica médica. Cambiaría el paradigma de “diagnóstico y tratamiento” por el de “predicción de riesgo y prevención”. Hace más de ...
Salivary gland morphology, tissue tropism and the progression of tospovirus infection in Frankliniella occidentalis
(2016)
Tomato spotted wilt virus (TSWV) is transmitted by thrips in a propagative manner; however, progression of virus infection in the insect is not fully understood. The goal of this work was to study the morphology and infection ...
Integration and Fixation Preferences of Human and Mouse Endogenous Retroviruses Uncovered with Functional Data Analysis
(2016-06-16)
Endogenous retroviruses (ERVs), the remnants of retroviral infections in the germ line, occupy ~8% and ~10% of the human and mouse genomes, respectively, and affect their structure, evolution, and function. Yet we still ...
Genetic diversity in Oryza glumaepatula wild rice populations in Costa Rica and possible gene flow from O. sativa
(2016-04-07)
Wild crop relatives are an important source of genetic diversity for crop improvement. Diversity estimates are generally lacking for many wild crop relatives. The objective of the present study was to analyze how genetic ...
Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats
(2016-07-12)
Transcript variation has important implications for organismal function in health and disease. Most transcriptome studies focus on assessing variation in gene expression levels and isoform representation. Variation at the ...
Neuropsychological Test Performance in Cognitively Normal Spanish-speaking Nonagenarians with Little Education
(2016-06)
To find associations of age, sex, and education with neuropsychological test performance in cognitively normal Spanish-speaking Costa Rican nonagenarians with little education; to provide norms; and to compare their ...
Hallazgos fenotípicos por imágenes con Tomografía Dental Volumétrica (TDV) en amelogénesis imperfecta
Use of Dental Volumetric Tomography for Dental Phenotyping In Amelogenesis Imperfecta
(2016)
Amelogénesis imperfecta (AI) se describe como un conjunto de defectos mendelianos en la biomineralización del esmalte dental, los cuales son severos en la mayoría de los casos al presentar anormalidades tales como un grosor ...
Molecular characterization and genetic diversity of Jatropha curcas L. in Costa Rica
(2017-02-09)
We estimated the genetic diversity of 50 Jatropha curcas samples from the Costa Rican germplasm bank using 18 EST-SSR, one G-SSR and nrDNA-ITS markers. We also evaluated the phylogenetic relationships among samples using ...