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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts
(2016-11-15)
The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of antifungal compounds from these bacteria, we discovered selvamicin, an ...
A time- and cost-effective strategy to sequence mammalian Y Chromosomes: an application to the de novo assembly of gorilla Y
(2016-02)
The mammalian Y Chromosome sequence, critical for studying male fertility and dispersal, is enriched in repeats and palindromes, and thus, is the most difficult component of the genome to assemble. Previously, expensive ...
Sobre el genoma humano, la medicina personalizada y el sistema de seguridad social
(2016)
La promesa del proyecto del genoma humano (PGH) fue que iba a transformar radicalmente la práctica médica. Cambiaría el paradigma de “diagnóstico y tratamiento” por el de “predicción de riesgo y prevención”. Hace más de ...
Molecular characterization and genetic diversity of Jatropha curcas L. in Costa Rica
(2017-02-09)
We estimated the genetic diversity of 50 Jatropha curcas samples from the Costa Rican germplasm bank using 18 EST-SSR, one G-SSR and nrDNA-ITS markers. We also evaluated the phylogenetic relationships among samples using ...
Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats
(2016-07-12)
Transcript variation has important implications for organismal function in health and disease. Most transcriptome studies focus on assessing variation in gene expression levels and isoform representation. Variation at the ...
Genetic diversity in Oryza glumaepatula wild rice populations in Costa Rica and possible gene flow from O. sativa
(2016-04-07)
Wild crop relatives are an important source of genetic diversity for crop improvement. Diversity estimates are generally lacking for many wild crop relatives. The objective of the present study was to analyze how genetic ...
Neuropsychological Test Performance in Cognitively Normal Spanish-speaking Nonagenarians with Little Education
(2016-06)
To find associations of age, sex, and education with neuropsychological test performance in cognitively normal Spanish-speaking Costa Rican nonagenarians with little education; to provide norms; and to compare their ...
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder
(2016-02-09)
Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity ...