Now showing items 31-34 of 34
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane ...
Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure−Activity Relationships
Tricyclic clerodane diterpenes (TCDs) are natural compounds that often show potent cytotoxicity for cancer cells, but their mode of action remains elusive. A computationally based similarity search (CDRUG), combined with ...
Leaf and flower essential oil compositions of Gliricidia sepium (Fabaceae) from Costa Rica
Gliricidia is a small genus of flowering plants in the Fabaceae family. Gliricidia sepium is a multipurpose tree native to Mesoamerica and possibly northern South America. The chemical composition of the hydrodistilled ...
Genetic analysis of the dry forest timber tree Sideroxylon capiri in Costa Rica using AFLP
Sideroxylon capiri (“Tempisque”) is a threatened and economically important timber species in the dry forest of Costa Rica. To assess the extent of the genetic diversity between and within populations of this species, 86 ...