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Inflammatory infiltrate in skeletal muscle injected with Bothrops asper venom

Artículo científico
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35_1986_RevBiolTrop_Gutiérrez_infiltrate_muscle_B.asper.pdf (1.390Mb)
Date
1986
Author
Gutiérrez, José María
Chaves Mora, Fernando
Cerdas Fallas, Luis
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Abstract
The time-course and composition of inflammatory infiltrate in mouse gastrocnemius injected with Bothrops asper venom was studied. The venom induced myonecrosis, and a prominent decrease in muscle levels of creatine kinase (CK) as early as 3 hr after envenomation. Inflammatory infiltrate was scarce by 6 hr. but increased markedly at 24, 48 and 72 hr. Samples of infiltrate obtained at 6 and 24 hr contained polymorphonuclear leucocytes as the predominant cell type, whereas at 48 hr and 72 hr the relative number of macrophages increased. Inflammatory cells were located within necrotic muscle cells, as well as in the interstitial space, but there were some necrotic areas devoid of inflammatory cells even one week after envenomation. When correlating the presence of inflammatory cells with degradation of myofibrillar proteins, it was observed that at 6 hr there was little muscle protein degradation. By 48 hr a decrease in "non collagen" proteins was observed, together with a reduction in some myofibrillar components, as judged by electrophoresis. Proteolytic enzymes of inflammatory cells may play an important role in myofibrillar protein degradation after myonecrosis induced by B. asper venom.
URI
http://hdl.handle.net/10669/29146
External link to the item
10.15517/rbt.v34i2.24233
Collections
  • Biología [938]
  • Revista de Biología Tropical Vol.34 (2) [3]



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  • Repositorios universitarios

  • Repositorio del SIBDI-UCR
  • Biblioteca Digital del CIICLA
  • Repositorio Documental Rafael Obregón Loría (CIHAC)
  • Biblioteca Digital Carlos Melendez (CIHAC)
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  • Colección de videos de UPA-VAS
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  • Buscador regional de LA Referencia
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  • Directory of Open Access Journals (DOAJ)
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Repositorio Institucional de la Universidad de Costa Rica. Algunos derechos reservados. Este repositorio funciona con DSpace.
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