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dc.creatorSegura Ruiz, Álvaro
dc.creatorVargas Arroyo, Mariángela
dc.creatorHerrera Vega, María
dc.creatorGonzález, Esteban
dc.creatorSolano Trejos, María Gabriela
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2016-11-16T20:04:15Z
dc.date.available2016-11-16T20:04:15Z
dc.date.issued2009-05
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S004101010900049Xes_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29257
dc.description.abstractLiquid formulations of antivenom require a cold chain for their distribution and storage, especially in tropical countries characterized by high temperature and humidity (climatic zone IV). Since cold chain is often deficient in many regions, there is a need to develop novel formulations of liquid antivenoms of higher stability at room temperatures. The effect of addition of the polyols mannitol and sorbitol on the thermal stability of caprylic acid-fractionated equine whole IgG antivenoms was assessed in preparations having different concentrations of protein and phenol. Results evidenced that: (1) turbidity increases proportionally to phenol and protein concentration. (2) After one year of storage at 25 °C, caprylic acid-purified antivenoms, formulated with or without polyols, did not show evidences of instability. (3) Formulation of antivenoms with 2.0 M sorbitol prevents the appearance of turbidity after one year storage at 37 °C; however, there was a partial loss in neutralizing potency in these conditions. Results suggest that formulation based on sorbitol is an option to obtain liquid whole IgG antivenoms of higher stability at tropical room temperatures.es_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 53, Número 6. 2009es_ES
dc.subjectAntivenomes_ES
dc.subjectIgGes_ES
dc.subjectF(ab′)2es_ES
dc.subjectStabilityes_ES
dc.subjectPolyolses_ES
dc.subjectClimatic zone IVes_ES
dc.subjectSorbitoles_ES
dc.subjectCaprylic acides_ES
dc.titleStability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperaturees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2009.01.012
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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