Show simple item record

dc.creatorSegura Ruiz, Álvaro
dc.creatorCastillo, M. C.
dc.creatorNúñez Rangel, Vitelbina
dc.creatorYarlequé, A.
dc.creatorGonçalves, Luís Roberto de Camargo
dc.creatorVillalta Arrieta, Mauren
dc.creatorBonilla, César
dc.creatorHerrera Vega, María
dc.creatorFernández, M.
dc.creatorYano, M. Y.
dc.creatorAraújo, H. P.
dc.creatorBoller, M. A. A.
dc.creatorLeón, P.
dc.creatorSano Martins, I. S.
dc.creatorGómez, A.
dc.creatorFernández, Gil Patrick
dc.creatorGeoghegan, Patricia
dc.creatorHigashi, Hisako Gondo
dc.creatorLeón Montero, Guillermo
dc.creatorGutiérrez, José María
dc.creatorTintaya, Benigno
dc.date.accessioned2016-11-28T16:39:24Z
dc.date.available2016-11-28T16:39:24Z
dc.date.issued2010-11
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010110002576es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/29321
dc.description.abstractSpecies of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, quality control and development of antivenoms in Latin America. The ability of seven polyspecific antivenoms, produced in Argentina, Brazil, Peru, Bolivia, Colombia and Costa Rica, to neutralize lethal, hemorrhagic, coagulant, defibrinogenating and myotoxic activities of the venoms of Bothrops neuwiedi (diporus) (Argentina), Bothrops jararaca (Brazil), B. neuwiedi (mattogrossensis) (Bolivia), Bothrops atrox (Peru and Colombia) and Bothrops asper (Costa Rica) was assessed using standard laboratory tests. Despite differences in the venom mixtures used in the immunization of animals for the production of these antivenoms, a pattern of extensive cross-neutralization was observed between these antivenoms and all the venoms tested, with quantitative differences in the values of effective doses. This study reveals the capacity of these antivenoms to neutralize, in preclinical tests, homologous and heterologous Bothrops venoms in Central and South America, and also highlight quantitative differences in the values of Median Effective Doses (ED50s) between the various antivenoms.es_ES
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnología para el Desarrollo/206AC0281/CYTED/Españaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.description.sponsorshipFundação Butantan///Brasiles_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 56, Número 6. 2010es_ES
dc.subjectBothropses_ES
dc.subjectAntivenomes_ES
dc.subjectNeutralizationes_ES
dc.subjectPreclinicales_ES
dc.subjectSnake venomes_ES
dc.titlePreclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venomses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2010.07.001
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record