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dc.creatorRehkopf, David H.
dc.creatorDow, William H.
dc.creatorRosero Bixby, Luis
dc.creatorLin, Jue
dc.creatorEpel, Elissa S.
dc.creatorBlackburn, Elizabeth H.
dc.date.accessioned2016-12-07T20:38:56Z
dc.date.available2016-12-07T20:38:56Z
dc.date.issued2013
dc.identifier.citationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819141/es_ES
dc.identifier.issn0531-5565
dc.identifier.urihttp://hdl.handle.net/10669/29364
dc.description.abstractStudies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere length than those in other parts of the country. After controlling for age, age squared, rurality, rainy season and gender, mean leukocyte telomere length in Nicoya was substantially longer (81 base pairs, p<0.05) than in other areas of Costa Rica, providing evidence of a biological pathway to which this notable longevity may be related. This relationship remains unchanged (79 base pairs, p<0.05) after statistically controlling for nineteen potential biological, dietary and social and demographic mediators. Thus the difference in mean leukocyte telomere length that characterizes this unique region does not appear to be explainable by traditional behavioral and biological risk factors. More detailed examination of mean leukocyte telomere length by age shows that the regional telomere length difference declines at older ages.es_ES
dc.description.sponsorshipWellcome Trust/[072406)]//Estados Unidoses_ES
dc.description.sponsorshipNational Institute on Aging/[P30AG012839]//Estados Unidoses_ES
dc.description.sponsorshipNational Institute on Aging/[R01AG031716]//Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceExperimental Gerontology; Volumen 48, Número 11, 2013es_ES
dc.subjectTelomere lengthes_ES
dc.subjectAginges_ES
dc.subjectBiomarkerses_ES
dc.subjectSocioeconomices_ES
dc.subjectLongevityes_ES
dc.subjectCosta Ricaes_ES
dc.titleLonger leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.exger.2013.08.005
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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