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dc.creatorBogarín, Guisella
dc.creatorMorais, Josefina Farina
dc.creatorYamaguchi, Ivone Kazuko
dc.creatorStephano, Marco Antonio
dc.creatorMarcelino, José Roberto
dc.creatorNishikawa, Amélia Keiko
dc.creatorGuidolin, Rosalvo
dc.creatorRojas Céspedes, Gustavo
dc.creatorHigashi, Hisako Gondo
dc.creatorGutiérrez, José María
dc.date.accessioned2017-01-24T21:51:02Z
dc.date.available2017-01-24T21:51:02Z
dc.date.issued2000-10
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010199002366es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29465
dc.description.abstractA study was performed on the ability of antivenoms, produced in Brazil and Costa Rica, to neutralize lethal, hemorrhagic and coagulant activities of the venoms of 16 species of Central and South American snakes of the subfamily Crotalinae. Neutralization of lethality was studied by two different methods routinely used in the quality control of antivenoms at Instituto Butantan (IB) and Instituto Clodomiro Picado (ICP). Both antivenoms neutralized the majority of the venoms studied, but the values of effective doses 50% (ED50) differed markedly depending on the method used. In general, higher potencies were obtained with the method of ICP, where a challenge dose corresponding to 4 LD50s is used, than with the method of IB, where a challenge dose of 5 LD50s is employed. All venoms induced hemorrhagic activity in the mouse skin test, which was effectively neutralized by the two antivenoms. All venoms, except those of Porthidium nasutum and Bothriechis lateralis, induced coagulation of human plasma in vitro and both antivenoms were effective in the neutralization of this activity. In conclusion, our results provide evidence of an extensive cross reactivity between these antivenoms and Central and South American crotaline snake venoms.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-89-057]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 38, Número 10, 2000es_ES
dc.subjectAntivenomes_ES
dc.subjectCrotalid Venomses_ES
dc.subjectAnimalses_ES
dc.subjectMicees_ES
dc.subjectNeutralization Testses_ES
dc.subjectSnake venomes_ES
dc.titleNeutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Ricaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/S0041-0101(99)00236-6
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-89-057
dc.identifier.pmid10758277


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