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dc.creatorEscalante Muñoz, Teresa
dc.creatorRucavado Romero, Alexandra
dc.creatorKamiguti, Aura S.
dc.creatorTheakston, R. David G.
dc.creatorGutiérrez, José María
dc.date.accessioned2017-02-07T20:05:07Z
dc.date.available2017-02-07T20:05:07Z
dc.date.issued2004-02
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010103003404es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29511
dc.description.abstractThe ability of the P-I metalloproteinase BaP1, isolated from the venom of the snake Bothrops asper, to induce systemic bleeding, thrombocytopenia and defibrinogenation was assessed in an experimental mouse model. Intravenous administration of BaP1 caused neither systemic bleeding nor any evidence of pathology in lungs, kidneys, liver, heart and brain. Moreover, there were no alterations in the whole blood clotting time or in platelet numbers. In addition, BaP1 did not inhibit collagen-induced platelet aggregation in vitro. Proteolytic and hemorrhagic activities of BaP1 were readily inhibited by the plasma proteinase inhibitor, α2-macroglobulin, and normal mouse serum also inhibited hemorrhage. Such inhibition may explain why BaP1 induces multiple local tissue-damaging effects, but is largely devoid of systemic toxicity.es_ES
dc.description.sponsorshipWellcome Trust([062043]/Inglaterraes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 43, Número 2. 2004es_ES
dc.subjectMetalloproteinasees_ES
dc.subjectSystemic Hemorrhagees_ES
dc.subjectCoagulopathyes_ES
dc.subjectBothrops Asper Venomes_ES
dc.subjectSnake venomes_ES
dc.titleBothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2003.11.012
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid15019481


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