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dc.creatorDos Santos, María Cristina
dc.creatorArroyo Portilla, Cynthia
dc.creatorSolano Rojas, Sergio
dc.creatorHerrera Vega, María
dc.creatorVillalta Arrieta, Mauren
dc.creatorSegura Ruiz, Álvaro
dc.creatorEstrada Umaña, Ricardo
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2017-02-22T20:39:43Z
dc.date.available2017-02-22T20:39:43Z
dc.date.issued2011-02
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010110004125es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29551
dc.descriptionEmbargo por política editorial 2081-01-02es_ES
dc.description.abstractAntivenoms are preparations of immunoglobulins purified from the plasma of animals immunized with snake venoms. Depending on the number of venoms used during the immunization, antivenoms can be monospecific (if venom from a single species is used) or polyspecific (if venoms from several species are used). In turn, polyspecific antivenoms can be prepared by purifying antibodies from the plasma of animals immunized with a mixture of venoms, or by mixing antibodies purified from the plasma of animals immunized separately with single venom. The suitability of these strategies to produce polyspecific antibothropic-crotalic antivenoms was assessed using as models the venoms of Bothrops asper, Crotalus simus and Crotalus durissus ruruima. It was demonstrated that, when used as co-immunogen, C. simus and C. durissus ruruima venoms exert a deleterious effect on the antibody response towards different components of B. asper venom and in the neutralization of hemorrhagic and coagulant effect of this venom when compared with a monospecific B. asper antivenom. Polyspecific antivenoms produced by purifying immunoglobulins from the plasma of animals immunized with venom mixtures showed higher antibody titers and neutralizing capacity than those produced by mixing antibodies purified from the plasma of animals immunized separately with single venom. Thus, despite the deleterious effect of Crotalus sp venoms on the immune response against B. asper venom, the use of venom mixtures is more effective than the immunization with separate venoms for the preparation of polyspecific bothropic–crotalic antivenoms.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 57, Número 2. 2011es_ES
dc.subjectSnake venomes_ES
dc.subjectBothrops asperes_ES
dc.subjectCrotalus simuses_ES
dc.subjectCrotalus durissus ruruimaes_ES
dc.subjectImmunizationes_ES
dc.subjectImmunomodulationes_ES
dc.subjectSnake antivenomes_ES
dc.titleComparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenomses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2010.11.016
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-A9-003
dc.identifier.pmid21130107


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