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dc.creatorSegura Ruiz, Álvaro
dc.creatorHerrera Vega, María
dc.creatorVillalta Arrieta, Mauren
dc.creatorVargas Arroyo, Mariángela
dc.creatorUscanga Reynell, Alfredo
dc.creatorPonce de León Rosales, Samuel
dc.creatorJiménez Corona, María Eugenia
dc.creatorReta Mares, José Francisco
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2017-02-27T21:31:30Z
dc.date.available2017-02-27T21:31:30Z
dc.date.issued2012-01
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010111003540es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29563
dc.descriptionVersión final embargada hasta 2082-01 por política editoriales_ES
dc.description.abstractBothrops asper is the species that induces the highest incidence of snakebite envenomation in southern Mexico, Central America and parts of northern South America. The intraspecies variability in HPLC profile and toxicological activities between the venoms from specimens collected in Mexico (Veracruz) and Costa Rica (Caribbean and Pacific populations) was investigated, as well as the cross-neutralization by antivenoms manufactured in these countries. Venoms differ in their HPLC profiles and in their toxicity, since venom from Mexican population showed higher lethal and defibrinogenating activities, whereas those from Costa Rica showed higher hemorrhagic and in vitro coagulant activities. In general, antivenoms were more effective in the neutralization of homologous venoms. Overall, both antivenoms effectively neutralized the various toxic effects of venoms from the two populations of B. asper. However, antivenom raised against venom from Costa Rican specimens showed a higher efficacy in the neutralization of defibrinogenating and coagulant activities, thus highlighting immunochemical differences in the toxins responsible for these effects associated with hemostatic disturbances in snakebite envenoming. These observations illustrate how intraspecies venom variation may influence antivenom neutralizing profile.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 59, Número 1. 2012es_ES
dc.subjectBothrops asperes_ES
dc.subjectSnake venomes_ES
dc.subjectIntraspecific variabilityes_ES
dc.subjectAntivenomes_ES
dc.subjectCross-neutralizationes_ES
dc.titleVenom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenomses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2011.11.005
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-A9-003
dc.identifier.pmid22119752


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