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dc.creatorOtero Patiño, Rafael
dc.creatorSegura Ruiz, Álvaro
dc.creatorPereañez, Jaime Andrés
dc.creatorHerrera Vega, María
dc.creatorAngulo Ugalde, Yamileth
dc.creatorLeón Montero, Guillermo
dc.creatorGutiérrez, José María
dc.creatorBarona, Jacqueline
dc.creatorEstrada, Sebastián
dc.creatorQuintana, Juan Carlos
dc.creatorVargas Muñoz, Leidy Johana
dc.creatorGómez, Juan Pablo
dc.creatorDíaz, Abel
dc.creatorSuárez, Ana María
dc.creatorFernández, Jorge
dc.creatorRamírez, Patricia
dc.creatorFabra, Patricia E.
dc.creatorPerea, Monica
dc.creatorFernández, Diego
dc.creatorArroyo, Yobana
dc.creatorBetancur, Dalila
dc.creatorPupo, Lady
dc.creatorCórdoba, Elkin
dc.creatorRamírez, Eugenio
dc.creatorArrieta, Ana Berta
dc.creatorRivero, Alcides
dc.creatorMosquera, Diana Carolina
dc.creatorConrado, Nectty Lorena
dc.creatorOrtiz, Rosina
dc.date.accessioned2017-03-24T18:09:18Z
dc.date.available2017-03-24T18:09:18Z
dc.date.issued2012-02
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010111003667es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/29615
dc.description2082-02 Embargo por política editoriales_ES
dc.description.abstractThe efficacy and safety of two polyvalent horse-derived antivenoms in Bothrops asper envenomings were tested in a randomized, double-blind, clinical trial performed in Colombia. Both antivenoms were manufactured from the same pool of hyperimmune plasma. Antivenom A was made of F(ab′)2 fragments, generated by pepsin digestion and caprylic acid precipitation, whereas antivenom B consisted of whole IgG molecules produced by caprylic acid precipitation followed by ion-exchange chromatography. Besides the different nature of the active substance, antivenom B had higher protein concentration, slightly higher turbidity and aggregate content. No significant differences were observed in the efficacy of antivenoms. Both halted local and systemic bleeding (P = 0.40) within 6–12 h of treatment in 100% of the cases, and restored blood coagulation (P = 0.87) within 6–24 h in 84.7% of patients, and within 48 h in all of them, in agreement with restoration of plasma fibrinogen concentration. Venom concentrations in serum dropped significantly (P < 0.001), to very low levels, 1 h after antivenom infusion. Nevertheless, eight patients (11.1%), four for each antivenom, presented recurrence of venom antigenaemia at different times, from 6 to 96 h, with clinical significance (recurrent coagulopathy) only in one group B patient (2.9%). Serum creatine kinase (CK) activity was increased, as a consequence of local myonecrosis. There was no significant difference (P = 0.51) in the incidence of early adverse reactions to antivenom administration (28.9% for patients of group A and 20.6% for patients of group B), most of the reactions being mild, mainly cutaneous. The most frequent complications were cellulitis (16.7%), abscess formation (5.6%), acute renal failure (8.3%), and compartmental syndrome (5.6%). In conclusion, IgG and F(ab′)2 antivenoms, prepared by caprylic acid fractionation, presented similar efficacy and safety profiles for the treatment of B. asper envenomings in Colombia.es_ES
dc.description.sponsorshipInstituto Colombiano para el Desarrollo de la Ciencia y la Tecnología Francisco José de Caldas//Colciencias/Colombiaes_ES
dc.description.sponsorshipUniversidad de Antioquia///Colombiaes_ES
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnología para el Desarrollo/[206AC0281]/CYTED/Españaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A9-003]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen, 59, Número 2, 2012,es_ES
dc.subjectAntivenomes_ES
dc.subjectVenomes_ES
dc.subjectEnvenominges_ES
dc.subjectBothrops asperes_ES
dc.subjectColombiaes_ES
dc.subjectIgGes_ES
dc.subjectF(ab0)2es_ES
dc.subjectCaprylic acid fractionationes_ES
dc.subjectEarly adverse reactionses_ES
dc.subjectSnake venomes_ES
dc.titleComparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab0)2] antivenoms, in Bothrops asper bites in Colombiaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2011.11.017
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid22146491


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