Show simple item record

dc.creatorVillalta Romero, Fabián
dc.creatorGortat, Anna
dc.creatorHerrera, Andrés E.
dc.creatorArguedas, Rebeca
dc.creatorQuesada Espinoza, Francisco Javier
dc.creatorLopes de Melo, Robson
dc.creatorCalvete Chornet, Juan José
dc.creatorMontero Villalobos, Mavis Lili
dc.creatorMurillo Masís, Renato
dc.creatorRucavado Romero, Alexandra
dc.creatorPérez Payá, Enrique
dc.date.accessioned2017-04-19T20:52:37Z
dc.date.available2017-04-19T20:52:37Z
dc.date.issued2012
dc.identifier.citationhttp://pubs.acs.org/doi/abs/10.1021/ml300068res_ES
dc.identifier.issn1948-5875
dc.identifier.urihttp://hdl.handle.net/10669/29627
dc.description.abstractThe majority of snakebite envenomations in Central America are caused by the viperid species Bothrops asper, whose venom contains a high proportion of zinc-dependent metalloproteinases that play a relevant role in the pathogenesis of hemorrhage characteristic of these envenomations. Broad metalloproteinase inhibitors, such as the peptidomimetic hydroxamate Batimastat, have been shown to inhibit snake venom metalloproteinases (SVMP). However, the difficulty in having open public access to Batimastat and similar molecules highlights the need to design new inhibitors of SVMPs that could be applied in the treatment of snakebite envenomations. We have chosen the SVMP BaP1 as a model to search for new inhibitors using different strategies, that is, screening of the Prestwick Chemical Library and rational peptide design. Results from these approaches provide clues on the structural requirements for efficient BaP1 inhibition and pave the way for the design of new inhibitors of SVMP.es_ES
dc.language.isoen_USes_ES
dc.sourceMedicinal Chemistry Letters; Volumen 3, Número 7. 2012es_ES
dc.subjectBaP1es_ES
dc.subjectMetalloproteinase inhibitorses_ES
dc.subjectProtein dockinges_ES
dc.subjectSnake venomes_ES
dc.subjectMetalloproteinaseses_ES
dc.titleIdentification of New Snake Venom Metalloproteinase Inhibitors Using Compound Screening and Rational Peptide Designes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1021/ml300068r
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Químicaes_ES
dc.identifier.pmid24900507


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record