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dc.creatorRojas Araya, Alicia
dc.creatorVargas Arroyo, Mariángela
dc.creatorRamírez Arguedas, Nils Antonio
dc.creatorEstrada Umaña, Ricardo
dc.creatorSegura Ruiz, Álvaro
dc.creatorHerrera Vega, María
dc.creatorVillalta Arrieta, Mauren
dc.creatorGómez Argüello, Aarón
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2017-06-09T17:37:01Z
dc.date.available2017-06-09T17:37:01Z
dc.date.issued2013-08
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010113001086es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30082
dc.description.abstractAntivenom pharmacokinetics has been studied in heterologous models in which the animal species used as immunoglobulin source is different from that used as recipient. In these models, after intravenous administration of antivenom, the plasma concentration of immunoglobulins shows a rapid initial declining-phase followed by a slower terminal-phase, which has been associated with antivenom distribution and elimination, respectively. We have compared pharmacokinetic parameters for equine-derived antivenom in homologous (horse) and heterologous (cow) models. It was found that the maximum concentration is lower in cows than in horses. Additionally, the steady-state distribution volume is higher in cows as compared to horses. On the other hand, models were not different in the time required to reach the maximum concentration, the area under the concentration/time curve, the half-life of decay during the slowest phase, the systemic clearance and the mean residence time. Similar results were obtained in a rabbit model, in which the pharmacokinetics was also affected by passive immunization of rabbits with anti-equine IgG. We conclude that, in addition to other physiological differences (e.g. cardiac frequency, plasmatic volume, glomerular filtration rate, etc.) between animal models, the ability to remove foreign immunoglobulins might influence the way in which the plasma concentration of antivenom decreases over time, thereby distorting the pharmacokinetic predictions based on non-compartmental models.es_ES
dc.description.sponsorshipInternational Foundation for Science/[B/5043-1]/IFS/Sueciaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B2-501]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volunmen 70. 2013es_ES
dc.subjectVenomes_ES
dc.subjectEquine immunoglobulinses_ES
dc.subjectAntivenomes_ES
dc.subjectPharmacokineticses_ES
dc.subjectHeterologyes_ES
dc.titleRole of the animal model on the pharmacokinetics of equine-derived antivenomses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2013.03.013
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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