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dc.creatorLaines, Johana
dc.creatorSegura Ruiz, Álvaro
dc.creatorVillalta Arrieta, Mauren
dc.creatorHerrera Vega, María
dc.creatorVargas Arroyo, Mariángela
dc.creatorAlvarez, Gladys
dc.creatorGutiérrez, José María
dc.creatorLeón Montero, Guillermo
dc.date.accessioned2017-06-14T21:24:48Z
dc.date.available2017-06-14T21:24:48Z
dc.date.issued2014-09-15
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010114001706es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30101
dc.description.abstractThe toxicological profile of the venoms of the snakes Bothrops asper and Bothrops atrox from Ecuador was investigated, together with the venom of a population of B. asper formerly classified as ‘Bothrops xanthogrammus’. The three venoms exerted lethal, hemorrhagic, myotoxic, coagulant and defibrinogenating effects, in agreement with the characteristic toxicological profile of Bothrops sp venoms. A polyspecific antivenom (bothropic–crotalic–lachesic) manufactured in Costa Rica was assessed for its preclinical efficacy against the toxic activities of these Ecuadorian venoms. Antivenom was effective in the neutralization of the five activities tested in the three venoms. These observations are in agreement with previous reports on the extensive cross-reactivity and paraspecific neutralization of antivenoms manufactured in Latin America against the venoms of Bothrops sp snakes.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B2-091]/UCR/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 88. 2014es_ES
dc.subjectBothrops asperes_ES
dc.subjectBothrops atroxes_ES
dc.subjectEcuadores_ES
dc.subjectAntivenomes_ES
dc.subjectToxicityes_ES
dc.subjectNeutralizationes_ES
dc.subjectSnake venomes_ES
dc.titleToxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Ricaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2014.06.008
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid24950051


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