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dc.creatorSánchez Céspedes, Laura Vanessa
dc.creatorPla Ferrer, Davinia
dc.creatorHerrera Vega, María
dc.creatorChippaux, Jean Philippe
dc.creatorCalvete Chornet, Juan José
dc.creatorGutiérrez, José María
dc.date.accessioned2017-07-07T13:34:39Z
dc.date.available2017-07-07T13:34:39Z
dc.date.issued2015-11
dc.identifier.citationhttp://www.sciencedirect.com/science/article/pii/S0041010115300878es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/30332
dc.description.abstractSnakebite envenoming causes a heavy toll in sub-Saharan Africa in terms of mortality and sequelae. In the West African savannah, the viperid Echis ocellatus is responsible for the vast majority of bites. In the last decades, several new antivenoms have been introduced for the treatment of these envenomings, although the assessment of their preclinical efficacy against the venom of E. ocellatus has been studied only for some of them. This work analyzed comparatively the ability of four antivenoms (FAV Afrique, EchiTAb G, EchiTAB-Plus-ICP®, and Inoserp™ Panafricain) to neutralize lethal, hemorrhagic, and in vitro coagulant activities of the venoms of E. ocellatus from Mali, Cameroon, and Nigeria. In addition, an immunoaffinity chromatography antivenomic protocol was used to assess the ability of the four antivenoms to bind to the proteins of these venoms. Results showed that all the antivenoms were effective in the neutralization of the three effects investigated, and were able to immunocapture, completely or partially, the most abundant components in the E. ocellatus venoms from the geographical origins sampled. Our observations also highlighted quantitative differences between antivenoms in their neutralizing and antivenomics profiles, especially regarding neutralization of in vitro coagulant activity, suggesting that different doses of these antivenoms are probably needed for an effective treatment of human envenomings by this species.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-B4-524]/UCR/Costa Ricaes_ES
dc.description.sponsorshipMinisterio de Educación y Ciencia/[BFU2007-61563]//Españaes_ES
dc.description.sponsorshipMinisterio de Ciencia é Innovación/[BFU2010-17373]//Españaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon; Volumen 106. 2015es_ES
dc.subjectEchis ocellatuses_ES
dc.subjectAntivenomes_ES
dc.subjectHemorrhagees_ES
dc.subjectLethalityes_ES
dc.subjectProcoagulant effectes_ES
dc.subjectNeutralizationes_ES
dc.subjectAntivenomicses_ES
dc.titleEvaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeriaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2015.09.027
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.pmid26415904


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