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dc.creatorRamírez Chan, Karol Gabriela
dc.creatorFornaguera Trías, Jaime
dc.creatorSheridan, John F.
dc.date.accessioned2018-02-14T13:22:49Z
dc.date.available2018-02-14T13:22:49Z
dc.date.issued2016
dc.identifier.citationhttps://link.springer.com/chapter/10.1007%2F7854_2016_25es_ES
dc.identifier.isbn978-3-319-51151-1
dc.identifier.isbn978-3-319-51152-8
dc.identifier.urihttp://hdl.handle.net/10669/74092
dc.description.abstractPsychosocial stress is capable of causing immune dysregulation and increased neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic systems that may contribute to the development of anxiety and depression. The stress model of repeated social defeat (RSD) recapitulates many of the stress-driven alterations in the neuroimmune system seen in humans experiencing repeated forms of stress and associated affective disorders. For example, RSD-induced neuronal and microglia activation corresponds with sympathetic outflow to the peripheral immune system and increased ability of bone marrow derived myeloid progenitor cells (MPC) to redistribute throughout the body, including to the central nervous system (CNS), reinforcing stress-associated behaviors. An overview of the neuroendocrine, immunological, and behavioral stress-induced responses will be reviewed in this chapter using RSD to illustrate the mechanisms leading to stress-related alterations in inflammation in both the periphery and CNS, and stress-related changes in behavioral responses.es_ES
dc.description.sponsorshipNational Institutes of Health/[R01-MH093473]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institutes of Health/[R01-MH097243]/NIH/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceInflammation-Associated Depression: Evidence, Mechanisms and Implications (pp 155-172). Switzerland: Springer International Publishinges_ES
dc.subjectAnxietyes_ES
dc.subjectDepressiones_ES
dc.subjectMicroglia activationes_ES
dc.subjectMonocyte traffickinges_ES
dc.subjectPsychosocial stresses_ES
dc.subjectSocial defeates_ES
dc.titleStress-Induced Microglia Activationand Monocyte Trafficking to the BrainUnderlie the Development of Anxietyand Depressiones_ES
dc.typeinfo:eu-repo/semantics/bookPartes_ES
dc.typeCapítulo de libroes_ES
dc.identifier.doi10.1007/7854_2016_25
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Odontologíaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES


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