Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom

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Date
2006
Author
Murakami, Mário T.
Melo, Cristiane C.
Angulo Ugalde, Yamileth
Lomonte, Bruno
Arni, Raghuvir K.
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Abstract
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 A ° resolution and the anion-binding site has been characterized.
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http://hdl.handle.net/10669/74162
External link to the item
10.1107/S1744309106010700
http://scripts.iucr.org/cgi-bin/paper?S1744309106010700
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