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dc.creatorLeón Montero, Guillermo
dc.creatorSegura Ruiz, Álvaro
dc.creatorHerrera Vega, María
dc.creatorOtero Patiño, Rafael
dc.creatorFrança, Francisco Oscar
dc.creatorBarbaro, Katia Cristina
dc.creatorCardoso, João Luiz Costa
dc.creatorWen, Fan Hui
dc.creatorde Medeiros, Carlos Roberto
dc.creatorPrado, José Carlos Lopes
dc.creatorMalaque, Ceila María Sant’Ana
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2018-03-08T22:00:50Z
dc.date.available2018-03-08T22:00:50Z
dc.date.issued2008
dc.identifier.citationhttp://www.jurology.com/article/S0035-9203(08)00209-5/abstractes_ES
dc.identifier.issn0035-9203
dc.identifier.issn1878-3503
dc.identifier.urihttp://hdl.handle.net/10669/74287
dc.description.abstractThe presence of human heterophilic antibodies against horse immunoglobulins (HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who received equine antivenom for therapy of snake bite envenoming. These patients were selected from two independent clinical studies: one in Colombia in which patients received antivenom constituted by whole IgG (n = 25); and the other in Brazil where an antivenom constituted by F(ab )2 fragments was administered (n = 31). Results show that healthy volunteers have antibodies, mainly of the IgG class, able to react with whole equine IgG. Additionally, patients have IgG antibodies that react both with whole equine IgG and F(ab )2 fragments. In both clinical studies, no significant differences were observed in the HHA-HI titres between the patients who presented early adverse (anaphylactoid) reactions and those who did not develop them. In addition, no variation in titre was observed in samples collected before and after antivenom administration. These results do not support the hypothesis that the incidence of early adverse reactions to antivenom administration correlates with the titre of HHA-HI in the serum of patients. Nevertheless, participation of these antibodies as part of a multifactorial pathogenic mechanism associated with these reactions cannot be ruled out.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A4-503]/UCR/Costa Ricaes_ES
dc.description.sponsorshipInstituto Colombiano para el Desarrollo de la Ciencia y la Tecnología Francisco José de Caldas//COLCIENCIAS/Colombiaes_ES
dc.description.sponsorshipUniversidad de Antioquia///Colombiaes_ES
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnología para el Desarrollo/[206AC0281]/CYTED/Españaes_ES
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo/[01/14426-2]/FAPESP/Brasiles_ES
dc.language.isoen_USes_ES
dc.sourceTransactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102, 1115-1119es_ES
dc.subjectantivenomes_ES
dc.subjectantibodieses_ES
dc.subjectSnake venomes_ES
dc.subjectIgGes_ES
dc.subjectAnaphylactic reactiones_ES
dc.subjectHeterophilic antibodieses_ES
dc.titleHuman heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administrationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.trstmh.2008.04.038
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-A4-503
dc.identifier.pmid18561967


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