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dc.creatorCalvete Chornet, Juan José
dc.creatorSanz, Libia
dc.creatorAngulo Ugalde, Yamileth
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.date.accessioned2018-03-12T20:04:27Z
dc.date.available2018-03-12T20:04:27Z
dc.date.issued2009
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0014579309002142es_ES
dc.identifier.issn0014-5793
dc.identifier.urihttps://hdl.handle.net/10669/74295
dc.description.abstractVenoms comprise mixtures of peptides and proteins tailored by Natural Selection to act on vital systems of the prey or victim. Here we review our proteomic protocols for uncoiling the composition, immunological profile, and evolution of snake venoms. Our long-term goal is to gain a deep insight of all viperid venom proteomes. Knowledge of the inter- and intraspecies ontogenetic, individual, and geographic venom variability has applied importance for the design of immunization protocols aimed at producing more effective polyspecific antivenoms. A practical consequence of assessing the cross-reactivity of heterologous antivenoms is the possibility of circumventing the restricted availability of species-specific antivenoms in some regions. Further, the high degree of target specificity makes toxins valuable scaffolds for drug development.es_ES
dc.description.sponsorshipUniversidad de Costa Rica/[741-A8-521]/UCR/Costa Ricaes_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas/[2007CR0004]/CSIC/Españaes_ES
dc.description.sponsorshipFundación Costa Rica - Estados Unidos para la Cooperación/[2007CR0004]/CRUSA/Estados Unidoses_ES
dc.description.sponsorshipPrograma Iberoamericano de Ciencia y Tecnología para el Desarrollo/[206AC0281]/CYTED/Españaes_ES
dc.description.sponsorshipConsejo Nacional de Rectores//CONARE/Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceFEBS Letters, vol. 583, 1736-1743es_ES
dc.subjectSnake venomes_ES
dc.subjectSnake venomicses_ES
dc.subjectAntivenomicses_ES
dc.titleVenom, venomics, antivenomicses_ES
dc.typeartículo científicoes_ES
dc.identifier.doi10.1016/j.febslet.2009.03.029
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.codproyecto741-A8-521
dc.identifier.pmid19303875


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