Show simple item record

dc.creatorLomonte, Bruno
dc.creatorAngulo Ugalde, Yamileth
dc.creatorMoreno Robles, Edgardo
dc.description.abstractLys49-phospholipase A2 homologues constitute a large family of toxins present in the venoms of viperid snake species, which despite lacking catalytic activity, cause significant skeletal muscle necrosis. The main structural determinants of this toxic effect have been experimentally mapped to a region near their C-terminus (115-129), which combines cationic and hydrophobic/aromatic amino acid residues. Short (13-mer) synthetic peptides representing this C-terminal region can mimick several of the effects of Lys49 PLA2 homologues. In addition to their ability to damage muscle cells, these peptides display antibacterial, antiendotoxic, antifungal, antiparasite, and antitumor activities, as well as VEGF-receptor 2 (KDR)-binding and heparin-binding properties. Modifications of their sequences have shown possibilities to enhance their effects upon prokaryotic cells, while decreasing toxicity for eukaryotic cells. This review presents an updated summary on the biomimetic actions exerted by such peptides, and highlights their potential value as molecular tools or as drug leads in diverse biomedical areas.es_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.description.sponsorshipInternational Foundation for Science//IFS/Sueciaes_ES
dc.description.sponsorshipConsejo Nacional para Investigaciones Científicas y Tecnológicas//CONICIT/Costa Ricaes_ES
dc.description.sponsorshipNetwork for Research and Training in Tropical Diseases in Central America//NeTropica/es_ES
dc.description.sponsorshipFundación Costa Rica - Estados Unidos para la Cooperación//CRUSA/Estados Unidoses_ES
dc.description.sponsorshipEmbajada de Japónv en Costa Rica///Japónes_ES
dc.description.sponsorshipLindbergh Foundation///Estados Unidoses_ES
dc.description.sponsorshipAmerican Society for Microbiology///Estados Unidoses_ES
dc.description.sponsorshipFlorida Ice & Farm///Costa Ricaes_ES
dc.description.sponsorshipConsejo Superior de Investigaciones Científicas//CSIC/Españaes_ES
dc.description.sponsorshipConsejo Nacional de Rectores//CONARE/Costa Ricaes_ES
dc.description.sponsorshipInternational Centre for Genetic Engineering and Biotechnology//ICGEB-CRP/Italiaes_ES
dc.rightsCC0 1.0 Universal*
dc.sourceCurrent Pharmaceutical Design, vol. 16, 3224-3230es_ES
dc.subjectPhospholipase A2es_ES
dc.subjectSynthetic peptideses_ES
dc.subjectSnake venomes_ES
dc.titleSynthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from Viperidae snake venoms: biomimetic activities and potential applicationses_ES
dc.typeArtículo científicoes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES

Files in this item


This item appears in the following Collection(s)

Show simple item record

CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal