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dc.creatorLomonte, Bruno
dc.creatorLeón Montero, Guillermo
dc.creatorAngulo Ugalde, Yamileth
dc.creatorRucavado Romero, Alexandra
dc.creatorNúñez Rangel, Vitelbina
dc.date.accessioned2018-03-13T16:46:07Z
dc.date.available2018-03-13T16:46:07Z
dc.date.issued2009
dc.identifier.citationhttps://www.sciencedirect.com/science/article/pii/S0041010109001780es_ES
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/10669/74299
dc.description.abstractInterest in studies on the neutralization of snake venoms and toxins by diverse types of inhibitors is two-fold. From an applied perspective, results enclose the potential to be translated into useful therapeutic products or procedures, to benefit patients suffering from envenomings. From a basic point of view, on the other hand, neutralizing agents may be used as powerful dissecting tools to determine the relative role of toxins within the context of the overall pathology induced by a venom, or to increase our understanding on the molecular mechanisms by which toxins exert their harmful actions upon particular targets. The venom of the snake Bothrops asper has been the subject of a number of experimental studies addressing its neutralization by antibodies, as well as by nonimmunologic inhibitors, including natural products derived from plants or animals, or synthetic drugs. As summarized in the present review, neutralization studies on this venom and some of its isolated toxins have contributed to a better understanding of envenomings by this species, and their treatment. In addition, such studies have provided valuable knowledge on the mechanisms of action and the relative functional importance of particular toxins of this venom, especially in the case of its myotoxic phospholipases A2 and hemorrhagic metalloproteinases.es_ES
dc.description.sponsorshipUniversidad de Costa Rica//UCR/Costa Ricaes_ES
dc.description.sponsorshipNetwork for Research and Training in Tropical Diseases in Central America//NeTropica/es_ES
dc.description.sponsorshipUniversidad de Antioquia///Colombiaes_ES
dc.description.sponsorshipDepartamento Administrativo de Ciencia, Tecnología e Innovación//COLCIENCIAS/Colombiaes_ES
dc.description.sponsorshipWellcome Trust///Reino Unidoes_ES
dc.description.sponsorshipInternational Foundation for Science//IFS/Sueciaes_ES
dc.language.isoen_USes_ES
dc.sourceToxicon, vol. 54(7), 1012-1028es_ES
dc.subjectAntivenomicses_ES
dc.subjectSnake venomes_ES
dc.subjectAntibodieses_ES
dc.subjectNatural productses_ES
dc.titleNeutralization of Bothrops asper venom by antibodies, natural products, and synthetic drugs: contributions to understanding snakebite envenomings and their treatmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1016/j.toxicon.2009.03.015
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.identifier.pmid19324064


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