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dc.creatorTaylor, James K.
dc.creatorPlaisance, Eric Paul
dc.creatorMestek, Michael L.
dc.creatorMoncada Jiménez, José
dc.creatorGrandjean, Peter Walter
dc.date.accessioned2018-07-04T16:36:41Z
dc.date.available2018-07-04T16:36:41Z
dc.date.issued2015
dc.identifier.citationhttps://www.tandfonline.com/doi/full/10.1179/1351000214Y.0000000103?scroll=top&needAccess=truees_ES
dc.identifier.issn1351-0002
dc.identifier.issn1743-292
dc.identifier.urihttp://hdl.handle.net/10669/75154
dc.description.abstractOur purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin (P > 0.05 for all). High-density lipoprotein particle size decreased by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise. PON1 activity increased 6.1% (P = 0.037) and PON1 concentrations increased 11.3% (P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.es_ES
dc.language.isoen_USes_ES
dc.sourceRedox Report Communications in Free Radical Research, Vol 20(1), pp. 41-48es_ES
dc.subjectParaoxonasees_ES
dc.subjectLipoprotein particle sizees_ES
dc.subjectLipid oxidationes_ES
dc.subjectExercisees_ES
dc.subjectNiacines_ES
dc.titleParaoxonase responses to exercise and niacin therapy in men with metabolic syndromees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1179/1351000214Y.0000000103
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro de Investigación en Ciencias del Movimiento Humano (CIMOHU)es_ES
dc.description.procedenceUCR::Vicerrectoría de Docencia::Ciencias Sociales::Facultad de Educación::Escuela de Educación Físicaes_ES


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