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dc.creatorMcEwen, Lisa M.
dc.creatorMorin, Alexander M.
dc.creatorEdgar, Rachel D.
dc.creatorMacIsaac, Julia L.
dc.creatorJones, Meaghan J.
dc.creatorDow, William H.
dc.creatorRosero Bixby, Luis
dc.creatorKobor, Michael S.
dc.creatorRehkopf, David H.
dc.date.accessioned2018-07-27T20:22:45Z
dc.date.available2018-07-27T20:22:45Z
dc.date.issued2017
dc.identifier.citationhttps://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-017-0128-2
dc.identifier.issn1756-8935
dc.identifier.urihttps://hdl.handle.net/10669/75304
dc.description.abstractBackground: The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypothesized to be a component of biological aging, we focused on this malleable epigenetic mark to determine its association with current residence in Nicoya versus elsewhere in Costa Rica. Examining a population’s unique DNA methylation pattern allows us to differentiate hallmarks of longevity from individual stochastic variation. These differences may be characteristic of a combination of social, biological, and environmental contexts. Methods: In a cross-sectional subsample of the Costa Rican Longevity and Healthy Aging Study, we compared whole blood DNA methylation profiles of residents from Nicoya (n = 48) and non-Nicoya (other Costa Rican regions, n = 47) using the Infinium HumanMethylation450 microarray. Results: We observed a number of differences that may be markers of delayed aging, such as bioinformatically derived differential CD8+ T cell proportions. Additionally, both site- and region-specific analyses revealed DNA methylation patterns unique to Nicoyans. We also observed lower overall variability in DNA methylation in the Nicoyan population, another hallmark of younger biological age. Conclusions: Nicoyans represent an interesting group of individuals who may possess unique immune cell proportions as well as distinct differences in their epigenome, at the level of DNA methylation.es_ES
dc.description.sponsorshipCenter on the Economics and Demography of Aging/[P30AG012839]/CEDA/Estados Unidoses_ES
dc.description.sponsorshipCanadian Institute of Health Research/[F16-00910]/CIHR/Canadáes_ES
dc.description.sponsorshipR. Howard Webster Foundation/[F13-00031]//Canadáes_ES
dc.description.sponsorshipNational Institute of Aging/[K01 AG047280]/NIA/Estados Unidoses_ES
dc.description.sponsorshipWellcome Trust Grant/[072406]//Reino Unidoes_ES
dc.description.sponsorshipCanadian Institute of Health Research/[F15‑04283]/CIHR/Canadáes_ES
dc.language.isoen_USes_ES
dc.sourceEpigenetics & Chromatin,vol.10(21),pp.1-14es_ES
dc.subjectMetilación de ADNes_ES
dc.subjectEpigeneticaes_ES
dc.subjectEnvejecimiento inmunees_ES
dc.subjectLongevidades_ES
dc.subjectBiodemografíaes_ES
dc.subject571.879 728 6 Longevidades_ES
dc.subjectDNA methylationes_ES
dc.subjectEpigeneticses_ES
dc.subjectImmune aginges_ES
dc.subjectLongevityes_ES
dc.subjectBiodemographyes_ES
dc.subjectEpigenetic agees_ES
dc.titleDifferential DNA methylation and lymphocyte proportions in a Costa Rican high longevity regiones_ES
dc.typeartículo científico
dc.identifier.doi10.1186/s13072-017-0128-2
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP)es_ES


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