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dc.creatorLaustsen, Andreas Hougaard
dc.creatorKaratt Vellatt, Aneesh
dc.creatorMasters, Edward W.
dc.creatorArias, Ana Silvia
dc.creatorPus, Urska
dc.creatorKnudsen, Cecilie
dc.creatorOscoz, Saioa
dc.creatorSlavny, Peter
dc.creatorGriffiths, Daniel T.
dc.creatorLuther, Alice M.
dc.creatorLeah, Rachael A.
dc.creatorLindholm, Majken
dc.creatorLomonte, Bruno
dc.creatorGutiérrez, José María
dc.creatorMcCafferty, John
dc.date.accessioned2019-01-15T15:49:31Z
dc.date.available2019-01-15T15:49:31Z
dc.date.issued2018
dc.identifier.citationhttps://www.nature.com/articles/s41467-018-06086-4es_ES
dc.identifier.urihttp://hdl.handle.net/10669/76386
dc.description.abstractThe black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both scarce on the African continent and present a number of drawbacks as they are derived from the plasma of hyper-immunized large mammals. Here, we describe the development of an experimental recombinant antivenom by a combined toxicovenomics and phage display approach. The recombinant antivenom is based on a cocktail of fully human immunoglobulin G (IgG) monoclonal antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba whole venom in a rodent model. Our results show the potential use of fully human monoclonal IgGs against animal toxins and the first use of oligoclonal human IgG mixtures against experimental snakebite envenoming.es_ES
dc.description.sponsorshipNovo Nordisk Foundation/[NNF16OC0019248]//Dinamarcaes_ES
dc.description.sponsorshipHørslev Foundation/[203866]//Dinamarcaes_ES
dc.description.sponsorshipOticon Foundation/[17-3802]//Dinamarcaes_ES
dc.description.sponsorshipUniversidad de Costa Rica - Instituto Clodomiro Picado/[]//Costa Ricaes_ES
dc.language.isoen_USes_ES
dc.sourceNature Communications, vol.9(3928), pp. 1-9.es_ES
dc.subjectSerpienteses_ES
dc.subjectVenenoes_ES
dc.subjectÁfricaes_ES
dc.subject615.946 Venenos animaleses_ES
dc.titleIn vivo neutralization of the dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG monoclonal antibodieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1038/s41467-018-06086-4
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES


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